1575698-85-9Relevant academic research and scientific papers
Synthesis of pyrazolo[3,4-d]-4,5-dihydropyrimidin-6-ones
Ryabukhin, Sergey V.,Granat, Dmitry S.,Plaskon, Andrey S.,Shivanyuk, Alexander,Lukin, Oleg
, p. 1846 - 1847 (2014/03/21)
A small library of hitherto unprepared pyrazolo[3,4-d]-4,5- dihydropyrimidin-6-ones was synthesized on a preparative scale. The synthesis starts with a substituted 5-aminopyrazole that reacts with an isocyanate to give the corresponding urea. The latter undergoes a chlorotrimethylsilane-promoted [5+1] cyclocondensation with an aldehyde yielding the title pyrazolo[3,4-d]-4,5- dihydropyrimidin-6-one. Both synthetic steps are high-yielding (74-94%). The intermediates and the target compounds were isolated by simple crystallization. Ketones with the exception of isatin do not react with the open-chain urea intermediates.
