1575727-97-7

Basic information

• Product Name: 1-(4-hydroxy-6-methylpyrimidin-2-yl)-4-(2-hydroxybenzylidene)-2-phenyl-1H-imidazol-5(4H)-one
• CAS NO: 1575727-97-7
• Molecular Weight: 372.383
• Mol File: 1575727-97-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-hydroxy-6-methylpyrimidin-2-yl)-4-(2-hydroxybenzylidene)-2-phenyl-1H-imidazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-hydroxy-6-methylpyrimidin-2-yl)-4-(2-hydroxybenzylidene)-2-phenyl-1H-imidazol-5(4H)-one(1575727-97-7)
• EPA Substance Registry System: 1-(4-hydroxy-6-methylpyrimidin-2-yl)-4-(2-hydroxybenzylidene)-2-phenyl-1H-imidazol-5(4H)-one(1575727-97-7)

Safety Data

• Hazardous Substances Data: 1575727-97-7(Hazardous Substances Data)

Upstream product

• 137401-66-2 N-2-hydroxyphenylmethylene-2-methyl-5-4H-oxazoline 
• 3977-29-5 2-amino-6-methylpyrimidin-4-ol 

Relevant articles and documents

Synthesis, in-vitroreverse transcriptase inhibitory activity and docking study of some new imidazol-5-one analogs

Non-nucleoside reverse transcriptase inhibitors have a definitive role and most commonly used in treatment of HIV-1 infection. A new series of 4-ethylidene/substituted-benzylidene-1-(4-hydroxy/chloro-6-methylpyrimidin-2-yl) -2-ethyl/phenyl-1H-imidazol-5(4H)-one were designed, synthesized, and evaluated for HIV-1 reverse transcriptase (RT) inhibitory activity. The results of in-vitro HIV-1 RT assay showed that some of the new compounds, such as 4c, 4d, 4e, 5a, and 5e effectively inhibit HIV-1 RT activity. 1-(4-Chloro-6- methylpyrimidin-2-yl)-4-(furan-2-ylmethylene)-2-methyl-1H-imidazol-5(4H)-one (5e) exerted most potent in-vitro HIV-1 RT inhibitory activity, among the group of compounds. Molecular docking studies were carried out to explore the binding affinity of imidazole-5-one analogs in active site of HIV-1 RT enzyme. Springer Science+Business Media 2014.