137401-66-2

Upstream product

• 90-02-8 salicylaldehyde 
• 543-24-8 N-acetylglycine 
• 5663-67-2 2-acetoxybenzaldehyde 

Downstream Products

• 127444-07-9 2-<5-(4-salicylidene-2-methyl-5-oxo-2-imidazolin-1-yl)-1,3,4-thiadiazol-2-ylthio>acetanilide 
• 127444-21-7 2-(5-{4-[1-(2-Hydroxy-phenyl)-meth-(E)-ylidene]-2-[(E)-2-(2-hydroxy-phenyl)-vinyl]-5-oxo-4,5-dihydro-imidazol-1-yl}-[1,3,4]thiadiazol-2-ylsulfanyl)-N-phenyl-acetamide 
• 1575727-59-1 1-(4-hydroxy-6-methylpyrimidin-2-yl)-4-(2-hydroxybenzylidene)-2-methyl-1H-imidazol-5(4H)-one 
• 1575727-97-7 1-(4-hydroxy-6-methylpyrimidin-2-yl)-4-(2-hydroxybenzylidene)-2-phenyl-1H-imidazol-5(4H)-one 
• 1575728-25-4 1-(4-chloro-6-methylpyrimidin-2-yl)-4-(2-hydroxybenzylidene)-2-methyl-1H-imidazol-5(4H)-one 
• 1575728-59-4 1-(4-chloro-6-methylpyrimidin-2-yl)-4-(2-hydroxybenzylidene)-2-phenyl-1H-imidazol-5(4H)-one 
• 937049-92-8 (4Z)-4-(2-hydroxybenzylidene)-1,2-dimethyl-1H-imidazol-5(4H)-one 
• 1394856-46-2 1-(4-acetylphenyl)-4-(2-hydroxybenzylidene)-2-methyl-1H-imidazol-5(4H)-one 
• 1394856-74-6 2-((1-(4-(4-(2-hydroxybenzylidene)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl)phenyl)ethylidene)hydrazono)thiazolidin-4-one 
• 1394856-59-7 2-(1-(4-(4-(2-hydroxybenzylidene)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl)phenyl)ethylidene)hydrazinecarbothioamide 
• 1373956-78-5 4-(2-hydroxybenzylidene)-2-methyl-1-(pyridin-4-ylmethyl)-1H-imidazol-5(4H)-one 
• 148875-03-0 N-[(2-{4-[1-(2-Hydroxy-phenyl)-meth-(Z)-ylidene]-2-methyl-5-oxo-4,5-dihydro-imidazol-1-yl}-phenylcarbamoyl)-methyl]-benzamide 

Relevant academic research and scientific papers

A synthesized GFP analogue emits via a hydrogen-bonding system

Two GFP analogues o-HBDI and o-HBMO have been designed and synthesized. The former shows no fluorescence while the latter shows strong fluorescence due to the formation of an intramolecular hydrogen-bond. At low temperatures, both molecules have strong fl

Facile synthesis, characterisation and anti-inflammatory activities of ferrocenyl ester derivatives of 4-arylidene-5-imidazolinones

This article describes the synthesis, optoelectronic properties and anti-inflammatory activities of a series of seven ferrocenyl ester-linked 4-arylidene-5-imidazolinone conjugates. Three different types of ortho-, meta- and para-substituted ferrocenyl es

New compounds having skin whitening, antioxidant and PPAR activity, and medical use thereof

PURPOSE: A novel compound with skin whitening, antioxidation, and PPAR activation effects, and a medical use thereof are provided to be used for a pharmaceutical composition or a cosmetic product. CONSTITUTION: A compound is denoted by chemical formula 1. A skin whitening composition contains the compound as an active ingredient. An antioxidative composition for preventing or treating oxidative diseases contains the compound of chemical formula 1 as an active ingredient. The oxidative diseases are selected among skin aging, pigmentation, wrinkling, psoriasis, or eczema. The composition prevents or treats diseases which are regulated by PPAR(peroxisome proliferator-activated receptor) activity. The PPAR includes PPAR alpha or PPAR gamma.

NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR

Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

Synthesis, in-vitroreverse transcriptase inhibitory activity and docking study of some new imidazol-5-one analogs

Non-nucleoside reverse transcriptase inhibitors have a definitive role and most commonly used in treatment of HIV-1 infection. A new series of 4-ethylidene/substituted-benzylidene-1-(4-hydroxy/chloro-6-methylpyrimidin-2-yl) -2-ethyl/phenyl-1H-imidazol-5(4H)-one were designed, synthesized, and evaluated for HIV-1 reverse transcriptase (RT) inhibitory activity. The results of in-vitro HIV-1 RT assay showed that some of the new compounds, such as 4c, 4d, 4e, 5a, and 5e effectively inhibit HIV-1 RT activity. 1-(4-Chloro-6- methylpyrimidin-2-yl)-4-(furan-2-ylmethylene)-2-methyl-1H-imidazol-5(4H)-one (5e) exerted most potent in-vitro HIV-1 RT inhibitory activity, among the group of compounds. Molecular docking studies were carried out to explore the binding affinity of imidazole-5-one analogs in active site of HIV-1 RT enzyme. Springer Science+Business Media 2014.

Microwave-assisted synthesis and antimicrobial screening of new imidazole derivatives bearing 4-thiazolidinone nucleus

A new series of compounds 2-((1-(4-(4-arylidene-2-methyl-5-oxo-4,5-dihydro- 1H-imidazol-1-yl)phenyl)ethylidene)hydrazono)thiazolidin-4-ones (4a-o) have been synthesized under conventional and microwave irradiation method. All compounds were characterized by IR, 1H NMR, 13C NMR and mass spectra. Newly synthesized compounds were screened for their antibacterial and antifungal activities on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus pyogenes, Candida albicans, Aspergillus niger and Aspergillus clavatus by bioassays, namely serial broth dilution. The synthesized compounds showed potent antimicrobial activity against tested microorganisms. Compounds 4h, 4j, 4m and 4n were the most potent amongst tested compounds.

Synthesis, biological activity and docking study of imidazol-5-one as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

A novel series of substituted imidazol-5-ones were designed, synthesized and evaluated for in vitro reverse transcriptase (RT) inhibition activity using reverse transcriptase assay kit (Roche, Colorimetric). It has been observed from in vitro screening that newly synthesized compounds possess RT inhibitory activity. Docking study was performed to study the binding orientation and affinity of synthesized compounds for RT enzyme.

Synthesis of substituted quinazolone derivatives as potential anti-HIV agents (part III)

Several 1-[2-phenyl-4(4H)-oxo-3-quinazolinyl]-2-methyl-4-arylidine -5-oxo-imidazolines (Va-1), 2-phenyl-3-(aroyl amino)-4(4H)-oxo quinazolines (Vla-I) and N1-2-methyl-4(4H)-oxo-3-quinazolinyl-N2-aryl-thioureas (Vlla-k), have been synthesised and tested for anti-HIV activity. The structures of these compounds have been established on the basis of elemental analysis and spectral data.

Synthesis of some new 2-methyl-4-(substituted benzylidene) 1-phenyl-1,2,4 triazolo [3,4,-b] 1,3,4 thiadiazole as potential AChE inhibitory agents

4-(1-aminophenyl) -1,2,4 - triazolo [3,4,-b] 1,3,4-thiadiozole (2) was prepared by treatment of 4-(1-aminophenyl)-5-mercapto-4-amino-1,2,4-S-triazole with carbondisulfide and KOH in methanol. This on further reaction with different 2-methyl-4-(substituted