157589-11-2Relevant academic research and scientific papers
Benzyl cation initiated intramolecular cyclizations. Synthesis of 1-azabicyclo[3.2.1]octene derivatives
Csuzdi, Emese,Pallagi, Istvan,Sziraki, Istvan,Solyom, Sandor
, p. 472 - 475 (2007/10/03)
Benzyl cation inititiated intramolecular cyclization reactions with conjugated C-C double bonds were performed providing rac. endo-exo isomers of 1-azabicyclo[3.2.1]octenes (2 and 3). Formation of the endo isomer 2 is favoured. Compounds 2 possess dopamine uptake inhibitory effect with an additional selective MAO-B enzyme inhibitory potential. The remarkable in vitro effects do not correspond to in vivo antidepressant activity. Johann Ambrosius Barth 1998.
