1576-70-1 Usage
Uses
Used in Dermatological Applications:
1-Methoxy-10H-phenothiazine is utilized as a photosensitizing agent for the treatment of skin disorders such as psoriasis and vitiligo. Its activation upon exposure to ultraviolet A (UVA) light leads to the formation of crosslinks with DNA, which inhibits cell division and results in the death of rapidly dividing cells. This targeted action is beneficial in managing skin conditions with excessive cell turnover.
Used in Oncological Research:
1-Methoxy-10H-phenothiazine is also being explored for its potential anti-cancer properties. Its capacity to interact with DNA upon UVA activation suggests possible applications in cancer therapy, particularly in targeting rapidly dividing cancer cells.
Used in Neurological Therapy Development:
Due to its ability to cross the blood-brain barrier, 1-Methoxy-10H-phenothiazine is considered a promising candidate for the development of neurological therapies. This characteristic allows for the potential treatment of conditions that require compounds to access the central nervous system.
Check Digit Verification of cas no
The CAS Registry Mumber 1576-70-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,7 and 6 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1576-70:
(6*1)+(5*5)+(4*7)+(3*6)+(2*7)+(1*0)=91
91 % 10 = 1
So 1576-70-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H11NOS/c1-15-10-6-4-8-12-13(10)14-9-5-2-3-7-11(9)16-12/h2-8,14H,1H3
1576-70-1Relevant academic research and scientific papers
Antioxidant activities of phenothiazines and related compounds: Correlation between the antioxidant activities and dissociation energies of O-H or N-H bonds
Yamamura, Tatsuo,Suzuki, Kyouichi,Yamaguchi, Tatsuya,Nishiyama, Tomihiro
, p. 413 - 419 (2007/10/03)
The antioxidant activities of phenothiazines, carbazoles, and related diphenylamines were evaluated in the oxidation of tetralin at 60°C and linoleic acid micelles in aqueous dispersion at 37°C induced by an azo initiator. Phenothiazines were highly antioxidant in both systems. Although diphenylamine and carbazole were not good antioxidants, those having a hydroxy group as a substituent at the ortho or para position to the amino group were potently antioxidant. The antioxidant activity of o-hydroxydiphenylamine was much greater than that of other compounds in both systems due to a stabilization of the phenoxyl radical by delocalization of the unpaired electron to the p-type lone pair of the amino group. A semiempirical MNDO-AM1 calculation was applied to study hydrogen abstractions of antioxidants in the chain process of autoxidation. These results indicated that the rates of oxidation during the induction period correlated with the dissociation energies of the O-H or N-H bonds.
