15761-83-8

Basic information

• Product Name: 5-PHENYL-2,4(1H,3H)-PYRIMIDINEDIONE
• Synonyms: 5-PHENYL-2,4(1H,3H)-PYRIMIDINEDIONE;AKOS BAR-0461;5-PHENYL-1H-PYRIMIDINE-2,4-DIONE;5-Phenylpyrimidine-2,4(1H,3H)-dione
• CAS NO: 15761-83-8
• Molecular Formula: C₁₀H₈N₂O₂
• Molecular Weight: 188.18
• Mol File: 15761-83-8.mol
• Article Data: 14

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.28g/cm³
• Refractive Index: 1.587
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-PHENYL-2,4(1H,3H)-PYRIMIDINEDIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYL-2,4(1H,3H)-PYRIMIDINEDIONE(15761-83-8)
• EPA Substance Registry System: 5-PHENYL-2,4(1H,3H)-PYRIMIDINEDIONE(15761-83-8)

Safety Data

• Hazardous Substances Data: 15761-83-8(Hazardous Substances Data)

Usage

General Description

5-PHENYL-2,4(1H,3H)-PYRIMIDINEDIONE is a chemical compound with the molecular formula C11H7N3O2. It is a pyrimidine derivative that is used in various applications, including as a building block in the synthesis of pharmaceuticals and other organic compounds. Its structure consists of a pyrimidine ring with a phenyl group attached at the 5-position and carbonyl groups at the 2 and 4 positions. 5-PHENYL-2,4(1H,3H)-PYRIMIDINEDIONE is of interest to researchers and chemists due to its versatile reactivity and potential for use in the development of new materials and bioactive compounds.

InChI:InChI=1/C10H8N2O2/c13-9-8(6-11-10(14)12-9)7-4-2-1-3-5-7/h1-6H,(H2,11,12,13,14)

Upstream product

• 116659-61-1 5-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 17838-69-6 ethyl 3-oxo-2-phenylpropanoate 
• 22275-34-9 5-phenyl-2,4,6-pyrimidinetrione 
• 143-66-8 sodium tetraphenyl borate 
• 696-07-1 5-iodouracil 
• 60734-12-5 3-hydroxy-2-phenylacrylic acid ethyl ester 
• 57-13-6 urea 
• 101-97-3 Ethyl 2-phenylethanoate 
• 685866-81-3 2,4-dimethoxy-5-phenylpyrimidine 
• 1309609-19-5 1,3-dibenzyl-5-phenylpyrimidine-2,4(1H,3H)-dione 
• 54-42-2 5-Iodo-2'-deoxyuridine 
• 98-80-6 phenylboronic acid 
• 71-43-2 benzene 
• 1431628-09-9 1-benzhydryl-5-phenyl-pyrimidine-2,4-dione 

Downstream Products

• 55377-22-5 1,3-dimethyl-5-phenylpyrimidine-2,4(1H,3H)-dione 
• 63558-77-0 2,4-dichloro-5-phenylpyrimidine 
• 259181-68-5 2,3'-anhydro-1-(5-O-benzoyl-2-deoxy-3-O-methanesulfonyl-β-D-threo-pentofuranosyl)-5-phenyluracil 
• 259181-67-4 1-(5-O-benzoyl-2-deoxy-3-O-methanesulfonyl-α-D-erythro-pentofuranosyl)-5-phenyluracil 
• 259181-66-3 1-(5-O-benzoyl-2-deoxy-3-O-methanesulfonyl-β-D-erythro-pentofuranosyl)-5-phenyluracil 
• 1428988-74-2 C₂₀H₁₆N₄O₄ 
• 1431627-85-8 N-hexyl-2,4-dioxo-5-phenyl-pyrimidine-1-carboxamide 
• 132363-35-0 3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-5-phenyl-1H-pyrimidine-2,4-dione 
• 132332-32-2 1-(2-methanesulfonyloxyethyl)-5-phenyl-2,4(1H,3H)-pyrimidinedione 
• 132332-33-3 1-(2-iodoethyl)-5-phenyl-2,4(1H,3H)-pyrimidinedione 
• 132332-31-1 1-(2-hydroxyethyl)-5-phenyl-2,4(1H,3H)-pyrimidinedione 
• 132332-35-5 2,3-dihydro-6-phenyl-7H-oxazolo<3,2-a>pyrimidin-7-one 
• 159042-25-8 1-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-phenyluracil 
• 159042-42-9 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-(p-nitrophenyl)cytosine 

Relevant articles and documents

Direct Arylation of 5-Iodouracil and 5-Iodouridine with Heteroarenes and Benzene via Photochemical Reaction

A method for the direct arylation of 5-iodouracil and 5-iodouridine was found to proceed in moderate yields. By irradiating mixtures of 5-iodouracil or 5-iodouridine and a series of five-membered heterocycles such as 1H-pyrrole, furan, 2-methylfuran, 1-methyl-1H-pyrrole, thiophene, as well as benzene in MeCN/H2O with a Hg lamp, 5-aryluracils and 5-aryluridines were synthesized. The reaction proceeded smoothly without the requirement of adding any transition metals or ligands.

ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS

The present invention concerns, in a first aspect, compounds of Formula I as defined herein, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing such compounds. The present invention also relates to compounds of Formula I

ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS

The present invention concerns, in a first aspect, compounds of Formula I as defined herein, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing such compounds. The present invention also relates to compounds of Formula I