63558-77-0

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dichloro-5-phenylpyrimidine is used as a building block for the synthesis of various drugs and pharmaceutical intermediates, contributing to the development of new therapeutic agents.
Used in Organic Synthesis:
2,4-Dichloro-5-phenylpyrimidine is used as a reagent in organic synthesis, facilitating the creation of complex organic compounds for a range of applications.
Used in Agrochemical Production:
2,4-Dichloro-5-phenylpyrimidine is used as a key component in the production of agrochemicals, playing a crucial role in the development of effective agricultural products.
Used in Cancer Research:
2,4-Dichloro-5-phenylpyrimidine is studied for its potential anti-cancer properties, with ongoing research aimed at understanding its role in inhibiting cancer cell growth and proliferation.
Used in Inflammation Management:
2,4-Dichloro-5-phenylpyrimidine is also being investigated for its anti-inflammatory properties, with potential applications in the treatment of various inflammatory conditions.

Upstream product

• 15761-83-8 5-phenyluracil 
• 36082-50-5 2,4-dichloro-5-bromopyrimidine 
• 98-80-6 phenylboronic acid 

Downstream Products

• 39860-32-7 2-chloro-4,5-diphenylpyrimidine 
• 685866-82-4 (2-chloro-5-phenyl-pyrimidin-4-yl)-(5-cyclopropyl-2H-pyrazol-3-yl)-amine 

Relevant academic research and scientific papers

Regioselective 2-Amination of Polychloropyrimidines

The regioselective amination of substituted di- and trichloropyrimidines affording the 2-substituted products is reported. While aryl- and heteroarylamines require the use of a dialkylbiarylphosphine-derived palladium catalyst for high efficiency, more nucleophilic dialkylamines produce 2-aminopyrimidines under noncatalyzed SNAr conditions. The key is the use of 5-trimethylsilyl-2,4-dichloropyrimidine as a surrogate for the parent dichloropyrimidine. For more challenging cases, the 2-chloro-4-thiomethoxy analogues were prepared and exclusively afford the desired 2-aminated-4-thiomethoxypyrimidine products.

Microwave-assisted, efficient and regioselective Pd-catalyzed C-phenylation of halopyrimidines

We herein report that flash heating microwave irradiation is a helpful tool in the formation of arylpyrimidines from the corresponding halopyrimidines. The palladium-catalyzed cross-coupling reactions of 2,4-di- and 2,4,5-trihalopyrimidines with phenylboronic acid under the above conditions are described. By use of the appropriate catalyst and the adequate halopyrimidine, good regioselectivity can be achieved in the 2-, 4-, or 5-positions of the heterocycle. In addition, we show that this methodology is ameneable for the stepwise preparation of mono-, di-, and triphenylpyrimidines.

PYRIMIDINE DERIVATIVES

The present invention provides a pyrimidine derivative represented by Formula (I) [wherein Ar represents substituted or unsubstituted aryl, etc., R1 represents -NR2R3 (wherein R2 represents a hydrogen atom or su

INDAZOLINONE COMPOSITIONS USEFUL AS KINASE INHIBITORS

The present invention provides compounds of formula (I): These compounds, and pharmaceutically acceptable compositions thereof, are useful generally as kinase inhibitors, particularly as inhibitors of PRAK, GSK3, ERK2, CDK2, MK2, SRC, SYK, and Aurora-2. Accordingly, compounds and compositions of the invention are useful for treating or lessening the severity of a variety of disorders, including, but not limited to, heart disease, diabetes, Alzheimer's disease, immunodeficiency disorders, inflammatory diseases, allergic diseases, autoimmune diseases, destructive bone disorders such as osteoporosis, proliferative disorders, infectious diseases and viral diseases.