157639-71-9

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 70-34-8 2,4-Dinitrofluorobenzene 
• 157639-67-3 (2S,3R,4E)-2-azido-1-benzoyloxy-octadec-4-ene-3-ol 
• 114299-64-8 (2S,3S,4E)-2-azido-3-O-(tert-butyldimethylsilyl)-4-octadecen-1,3-diol 
• 103348-49-8 2-azido-sphingosine 
• 157639-70-8 (2S,3R,4E)-3-(tert-butyldimethylsilyloxy)-2-(2,4-dinitrophenyl)amino-4-octadecen-1-ol 

Downstream Products

• 157639-66-2 (2S,3R,4E)-1-<5a-carba-β-D-xylo-hex-5(5a)-enopyranosylamino>-2-(2,4-dinitrophenyl)amino-4-octadecen-3-ol 
• 157639-65-1 (2S,3R,4E)-3-tert-butyldimethylsilyloxy-1-<2,3:4,6-di-O-isopropylidene-5a-carba-β-D-xylo-hex-5(5a)-enopyranosylamino>-2-(2,4-dinitrophenyl)amino-4-octadecene 
• 162020-01-1 (2S,3R,4E)-1-(5a-carba-β-D-glucopyranosylthio)-2-(2,4-dinitrophenyl)amino-4-octadecen-3-ol 
• 162019-91-2 (2S,3R,4E)-3-(tert-butyldimethylsilyloxy)-1,2-(2,4-dinitrophenyl)imino-4-octadecene 

Relevant academic research and scientific papers

Synthesis of 5a-Carba-&β-D-glycosylceramide Analogs Linked by Imino, Ether and Sulfide Bridges

Carbocyclic analogs of glycoceramides, (2S,3R,4E)-1-(5a-carba-β-D-glycopyranosyl)-2-(hexadecanoylamino)-4-octadecen-3-ols E-3 - E-6, linked by imino, ether and sulfide bridges, were synthesized by coupling of aziridines, as the sphingosine precursors, wit

Synthesis of glucosylceramide analogues. Imino-linked 5a-carbaglycosylceramides, potent and specific glucocerebrosidase inhibitors

Imino-linked carbocyclic analogues (E)- and (Z)-2 of glucosylceramide 1 have been synthesized and shown to be potent and specific inhibitors against glucocerebrosidase.