157640-50-1Relevant academic research and scientific papers
A newly devised method for the debenzylation of N6-benzyladenosines. A convenient synthesis of [6-15N]-labeled adenosines
Sako,Ishikura,Hirota,Maki
, p. 1239 - 1246 (1994)
[6-15N]-Labeled adenosine was conveniently prepared from inosine (1a) by the silylation-benzylamination of 1a and subsequent oxidative debenzylation with ammonium peroxydisulfate in a pH 7.2 buffer solution.
4,4′-Dimethoxytrityl and 4,4′,4″-trimethoxytrityl as protecting groups for amino functions; selectivity for primary amino groups and application in 15N-labelling
Henderson, Alistair P.,Riseborough, Jane,Bleasdale, Christine,Clegg, William,Elsegood, Mark R. J.,Golding, Bernard T.
, p. 3407 - 3413 (2007/10/03)
4,4′-Dimethoxytrityl tetrafluoroborate (DMT+ BF4-) and 4,4′,4″-trimethoxytrityl tetrafluoroborate (TMT+ BF4-) are useful reagents for protecting primary and some secondary amines. Protected amines are obtained either by reaction of DMT+ BF4- or TMT+ BF4- with the amine or by alkylating DMT- or TMT-amine (available from DMT+ BF4- and TMT+ BF4- by treatment with ammonia). Alkylation of DMT- or TMT-amine stops after monoalkylation. Deprotection of the alkylated DMT- and TMT-amine is achieved by treatment with an acid of appropriate molarity (e.g. 0.1 M HCl in 1:1 tetrahydrofuran-water for TMT-amines). The value of the methodology described is illustrated by a synthesis of (15NH2) adenosine. X-Ray molecular structures of one DMT and two TMT derivatives are reported.
