157642-22-3Relevant academic research and scientific papers
REACTION OF ETHYL 5-SUBSTITUTED-2-FUROYLMALONATES WITH SECONDARY AMINES
Kada, Rudolf,Brunckova, Jarmila,Bobal, Pavol
, p. 1400 - 1407 (1994)
In situ prepared magnesium salts of ethyl malonate react with 5-X-2-furoyl chlorides (X=Br.NO2.C6H5S and C6H5SO2) to give the corresponding ethyl 5-X-2-furoylmalonates.On treatment of these compounds with secondary amines no nucleophilic substitution of the group X in position 5 of the furan nucleus took place but, instead, amides of 5-X-2-furancarboxylic acids were isolated.
