157664-03-4

Basic information

• Product Name: 7-Xylosyl-10-deacetylbaccatin III
• Synonyms: 7-Xylosyl-10-deacetylbaccatin III;10-O-Deacetyl-7-O-beta-D-xylopyranosylbaccatin III
• CAS NO: 157664-03-4
• Molecular Formula: C₃₄H₄₄O₁₄
• Molecular Weight: 676.70476
• Mol File: 157664-03-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Xylosyl-10-deacetylbaccatin III(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Xylosyl-10-deacetylbaccatin III(157664-03-4)
• EPA Substance Registry System: 7-Xylosyl-10-deacetylbaccatin III(157664-03-4)

Safety Data

• Hazardous Substances Data: 157664-03-4(Hazardous Substances Data)

Usage

General Description

7-Xylosyl-10-deacetylbaccatin III is a chemical compound also known as 7-xylosyltaxol, which is a semi-synthetic precursor of the anticancer drug paclitaxel. It is derived from the Pacific yew tree and belongs to the taxane family of compounds. This chemical has potent antitumor activity by disrupting microtubule dynamics, leading to cell cycle arrest and apoptosis. 7-Xylosyl-10-deacetylbaccatin III has been studied for its potential use in cancer treatment and has shown promising results in preclinical and clinical trials. Its structure and properties make it a valuable starting material for the synthesis of paclitaxel and other taxane derivatives.

Upstream product

• 90332-63-1 7-O-(β-xylosyl)-10-deacetyltaxol 

Downstream Products

• 32981-86-5 10-deacetylbaccatin III 

Relevant articles and documents

Microbial hydrolysis of 7-xylosyl-10-deacetyltaxol to 10-deacetyltaxol

Enterobacter sp. CGMCC 2487, a bacterial strain isolated from the soil around a Taxus cuspidata Sieb. et Zucc. plant, was able to remove the xylosyl group from 7-xylosyltaxanes. The xylosidase of this strain was an inducible enzyme. In the bioconversion of 7-xylosyl-10-deacetyltaxol (7-XDT) to 10-deacetyltaxol (10-DT), for the purpose of enhancing the conversion efficiency, the effects of NH4+, oat xylan, temperature, pH value, cell density and substrate concentration on the bioconversion have been systematically investigated. 3.0 mM NH4+, 0.6% oat xylan in the media could enhance the yield of 10-DT; the optimum biocatalytic temperature was 26 °C and optimum pH value was 6.0. The highest conversion rate and yield of 10-DT from 7-XDT reached 92% and 764 mg/L, respectively. In addition, the biocatalytic capacity of the cell cultures remained 66.1% after continuous three batches. These results indicate that converting 7-XDT to 10-DT, a useful intermediate for the semisynthesis of paclitaxel or other taxane-based anticancer drugs by a novel bacterial strain, Enterobacter sp. CGMCC 2487, would be an alternative for the practical application in the future.