90332-63-1

Usage

Uses

Used in Pharmaceutical Industry:
7-Xylosyl-10-deacetyltaxol is used as a research compound for investigating its potential biological activities and therapeutic effects. As a metabolite of Paclitaxel, it may exhibit similar or distinct anticancer properties, which can be explored for the development of novel cancer treatments.
Used in Drug Metabolism Studies:
In the field of drug metabolism, 7-Xylosyl-10-deacetyltaxol serves as an important marker for understanding the metabolic pathways of Paclitaxel. Studying its formation, distribution, and elimination can provide valuable insights into the pharmacokinetics and pharmacodynamics of Paclitaxel, potentially leading to improved drug formulations and personalized treatment strategies.
Used in Quality Control and Impurity Profiling:
7-Xylosyl-10-deacetyltaxol is used as an in-house impurity in the quality control and manufacturing processes of Paclitaxel. Monitoring the presence and levels of this metabolite in Paclitaxel formulations ensures the purity, safety, and efficacy of the drug, ultimately benefiting patients undergoing cancer treatment.

Downstream Products

• 157664-03-4 7-β-D-xylosylbaccatin III 

Relevant academic research and scientific papers

Preparation method of 7-xylosyltaxol

The invention relates to a preparation method of 7-xylosyltaxol, and belongs to the technical field of preparation of taxane anticancer drugs, the preparation method comprises the following steps: S1, dissolving a 7-xylosyl-10-deacetylpaclitaxel extract with dichloromethane and pyridine, dropwise adding 2,2,2-trichloroethyl chloroformate while stirring, and reacting to obtain a product I; S2, dissolving the product I in methanol and acetic acid, adding zinc powder, and stirring for reaction to obtain a product II; S3, dissolving the product II in tetrahydrofuran, adding cerium trichloride, dropwise adding acetic anhydride, and stirring for reaction to obtain a product III; and S4, dissolving the product III in methanol, adding a 30% dimethylamine methanol solution, and carrying out a stirring reaction to obtain the 7-xylosyltaxol. The method has the advantages of accessibility of initial materials, mild reaction conditions and high purity of target products, and can be used for large-scale preparation.

METHOD FOR THE PRODUCTION OF TAXOL AND/OR TAXANES FROM CULTURES OF HAZEL CELLS

Method for the production of taxol and/or taxanes, comprising the steps of: a) inducing the formation of callus from a plant tissue explant, through in vitro culturing in a suitable nutritient medium, b) cultivating the callus in a liquid medium to obtain a cell suspension culture capable of producing taxol and/or taxanes, c) recovering the taxol and/or the taxanes from the cells and/or from the culture medium of the cell suspension obtained from the callus in which the tissue explant is obtained from a plant of the genus Corylus, in particular Corylus avellana.