157664-10-3Relevant academic research and scientific papers
An Efficient General Route to Furo-, Pyrido- and Thieno-benzazepines via Pd0 Catalysed Cross Coupling Reactions and Nitrile Ylide Cyclisations
Finch, Harry,Reece, Donald H.,Sharp, John T.
, p. 1193 - 1204 (2007/10/02)
The cyclisation of diene-conjugated nitrile ylides of the general type 1, in which the conjugated system consists of a benzene ring and a five- or a six-membered heterocyclic ring, provides an effective route to fully unsaturated heterocyclobenzazepines.The combination of this cyclisation with a direct route to the nitrile ylide precursors via Pd0 catalysed cross-coupling gives an efficient general synthetic route to these systems from readily available starting materials.
