15770-21-5Relevant articles and documents
Pairing of α-Fused BODIPY: Towards Panchromatic n-Type Semiconducting Materials
Huaulmé, Quentin,Fall, Sadiara,Lévêque, Patrick,Ulrich, Gilles,Leclerc, Nicolas
, p. 6613 - 6620 (2019)
A chemical strategy to efficiently perform the dimerization of α-fused boron-dipyrromethene (BODIPY) is reported. The straightforward synthesis of one of these dimers is described and its properties have been investigated through UV/Vis spectroscopy, cyclic voltammetry, differential scanning calorimetry, and charge-carrier mobility measurements by using organic field-effect transistors and space–charge-limited current diodes. The results allow a chemical strategy to decrease the tendency of α-fused BODIPY to crystallize, to increase its light-harvesting properties, and to promote isotropic charge carriers transport. Moreover, the disclosed approach is also a way to maintain the deep LUMO level of α-fused BODIPY; thus making this class of materials highly desirable for optoelectronic applications.
Synthesis and photodynamic activity of novel non-symmetrical diaryl porphyrins against cancer cell lines
Caruso, Enrico,Cerbara, Monica,Malacarne, Miryam Chiara,Marras, Emanuela,Monti, Elena,Gariboldi, Marzia Bruna
, p. 39 - 50 (2019)
Photodynamic therapy (PDT)of cancer uses photosensitizers (PS), a light source and oxygen to generate high levels of reactive oxygen species (ROS), that exert a cytotoxic action on tumor cells. Recently, it has been shown that mixed non-symmetrical diaryl porphyrins, with two different pendants, are more photodynamically active than symmetrical diaryl porphyrins. In the present study, we investigate the in vitro photodynamic effects of four novel non-symmetrical diaryl porphyrins, two of which bear one pentafluoro-phenyl and one bromo-alkyl (apolar)pendant, whereas the two others bear one pentafluoro-phenyl and one cationic pyridine pendant. The four compounds were tested in a small panel of human cancer cell lines, and their photodynamic activities were compared with that of m-THPC (Foscan), currently the most successful PS approved for clinical use in cancer PDT. The results of the cytotoxicity studies indicate that the two molecules bearing the cationic pendant are more potent in vitro than those with the apolar pendant, and that they are as potent as Foscan. To gain further insights into the mechanism of PS-induced phototoxicity, induction of apoptotic, autophagic and necrotic cell death, and generation of reactive oxygen species (ROS)were evaluated in cancer cells following exposure to the PSs and irradiation. The effect of the PSs on the migratory activity of the cells was also assessed. The data obtained from this work support a greater potency of diaryl porphyrins with a positive charge in inducing cell death, as compared to those with the bromo-alkyl pendant; most importantly, some of these novel compounds exhibit features that might make them superior to the clinically approved PS Foscan.
COMPOUND, COLOR CONVERSION FILM COMPRISING SAME, BACK-LIGHT UNIT, AND DISPLAY DEVICE
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Paragraph 0161-0163; 0172, (2021/05/21)
The present specification relates to a compound represented by Chemical Formula 1, and a color conversion film, a backlight unit and a display apparatus including the same.
Boron Dipyrromethene (BODIPY) as Electron-Withdrawing Group in Asymmetric Copper-Catalyzed [3+2] Cycloadditions for the Synthesis of Pyrrolidine-Based Biological Sensors
Alemán, José,Asenjo-Pascual, Juan,Cordani, Marco,Díaz-Tendero, Sergio,Fraile, Alberto,Martín-Somer, Ana,Milán Rois, Paula,Rigotti, Thomas,Somoza, álvaro
supporting information, (2020/02/20)
In this work, we describe the use of Boron Dipyrromethene (BODIPY) as electron-withdrawing group for activation of double bonds in asymmetric copper-catalyzed [3+2] cycloaddition reactions with azomethine ylides. The reactions take place under smooth conditions and with high enantiomeric excess for a large number of different substituents, pointing out the high activation of the alkene by using a boron dipyrromethene as electron-withdrawing group. Experimental, theoretical studies and comparison with other common electron-withdrawing groups in asymmetric copper-catalyzed [3+2] cycloadditions show the reasons of the different reactivity of the boron dipyrromethene derivatives, which can be exploited as a useful activating group in asymmetric catalysis. Additional experiments show that the so obtained pyrrolidines can be employed as biocompatible biosensors, which can be located in the endosomal compartments and do not present toxicity in three cell lines. (Figure presented.).
Modifiable hyperconjugation triple molten porphyrin dimer strong two-photon absorption material and preparation thereof
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Paragraph 0045; 0048, (2020/11/09)
The invention relates to a modifiable hyperconjugation triple molten porphyrin dimer strong two-photon absorption material and preparation thereof. In two edge meso positions of a porphyrin dimer, oneof the two edge meso positions of the porphyrin dimer is provided with anilino, and the other of the two edge meso positions of the porphyrin dimer is provided with acetanilino. Compared with the prior art, the preparation method comprises the following steps: selectively modifying aniline groups on single porphyrin with vacancy at double meso sites in a unilateral manner, performing protection in advance, further separating out a symmetrical molten porphyrin dimer with two acetanilide groups through low-temperature oxidation and low-temperature extraction modes, and finally preparing a target compound with one anilino group and one acetanilino group through a unilateral deprotection reaction, namely the asymmetric triple molten porphyrin dimer TFP. The material not only has the strong TPA characteristic of the triple molten porphyrin dimer, but also is very easy to modify, provides possibility for preparing diversified nonlinear and other functional materials with a wider applicationrange, and has a good application prospect.
