1577067-67-4Relevant articles and documents
Metal-free, one-pot, rapid synthesis of tetrahydropyridines using acetic acid as solvent and catalyst at room temperature
Balijapalli, Umamahesh,Munusamy, Sathishkumar,Sundaramoorthy, Karthikeyan Natesan,Iyer, Sathiyanarayanan Kulathu
, p. 943 - 953 (2014)
Acetic acid-promoted, one-pot synthesis of tetrahydropyridines has been developed under metal-catalyst-free conditions via a tandem reaction. High atom economy, good yield, simple procedure, no expensive column chromatography, shorter reaction time, and metal-free and mild reaction conditions are some of the important features of this protocol. The current methodology provides an alternative approach for not only highly substituted tetrahydropyridines (THPs) but also fully substituted tetrahydropyridines (FTHPs) in moderate to good yields. The plausible mechanism for the formation of THPs was greatly promoted by the H+ ion coming from acetic acid. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]