1577186-75-4

Upstream product

• 92638-98-7 4-(furan-2-yl)butyric acid 
• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 90005-38-2 4-(furan-2-yl)butanenitrile 
• 92513-83-2 furnish 2-(3-bromopropyl)furan 

Downstream Products

• 1577186-77-6 2‘-desoxy-2‘[4-(2-furyl)butanamido]-5’O-(4,4‘-dimethoxytrityl)uridine 
• 1577186-78-7 2‘-desoxy-2‘-[(4-(2-furyle)butanamido)]-5‘-O-(4,4‘-dimethoxytrityl)-uridine-3’-(2-cyanoethyl)-N,N-diisopropyle phosphoramidite 

Relevant academic research and scientific papers

Synthesis of DNA conjugates with metalated tetracationic porphyrins by postsynthetic cycloadditions

Tetracationic porphyrins of the TMPP (meso-tetra-(4-N-methylpyridyl) porphyrin) type, metalated with Cu(II) or with Au(III), were conjugated covalently to oligonucleotides. The Cu(I)-catalyzed cycloaddition (between an azide and an ethynyl group) and the Diels-Alder cycloaddition (between a furan and a maleimide functionality) were successfully applied as two alternative postsynthetic methods to modify the 2′-position of an internal uridine. Melting temperatures and UV/vis absorption properties were compared. CD measurements indicated that the type of conjugation chemistry determines the grade of intercalation of the attached and positively charged porphyrins.