1577232-61-1

Upstream product

• 105-53-3 diethyl malonate 
• 766-97-2 4-n-methylphenylacetylene 
• 74-83-9 methyl bromide 
• 63104-44-9 dimethyl 2,2-di(prop-2-ynyl)malonate 
• 536-74-3 phenylacetylene 
• 2689-88-5 diethyl 2,2-di(prop-2-yn-1-yl)malonate 
• 33491-05-3 1-(2-bromoethynyl)-4-methylbenzene 

Downstream Products

• 1577232-48-4 diethyl 7-bromo-5-(p-tolyl)-4-(p-tolylethynyl)-1H-indene-2,2(3H)-dicarboxylate 

Relevant academic research and scientific papers

Epoxyanthracene Derivatives and Dicarbonylation on Benzene Ring via Hexadehydro-Diels-Alder (HDDA) Derived Benzynes with Oxazoles

A capture reaction of hexadehydro-Diels-Alder (HDDA) derived benzyne with various substituted oxazoles is reported. With methyl, hydrogen, or phenyl as the substituent at 2-position of oxazole, tetraynes afforded epoxyanthracene derivatives or underwent dicarbonylation on benzene ring. The reaction does not require any catalyst or additive. The mechanism behind the reaction was investigated. The obtained polycyclic product structure has potential application value in optoelectronic materials. The availability of dicarbonylated arene implies the uniqueness of HDDA benzyne reaction compared with traditional benzyne.

Fully Substituted Conjugate Benzofuran Core: Multiyne Cascade Coupling and Oxidation of Cyclopropenone

An unprecedented C═C double bond cleavage of cyclopropenone and dioxygen activation by multiyne cascade coupling has been developed. This chemistry provides a novel, simple, and efficient approach to synthesize fully substituted conjugate benzofuran derivatives from simple substrates under mild conditions. The density functional theory (DFT) calculations reveal that the unique homolytic cleavages of cyclopropenone and molecular oxygen are crucial to the success of this reaction.

Synthesis method of benzoxazolidine derivative

The invention relates to a synthesis method of a benzoxazolidine derivative, the tetrayne compound and the 5, 5-dimethyl-1-pyrroline-N-oxide are subjected to a heating condensation reflux reaction, the reaction conditions are mild, and the synthesis method is simple. Compared with the prior art, the invention provides a brand-new synthesis method of the benzoxazolidine derivative, and a series of new benzoxazolidine derivatives are generated. The synthesized benzoxazolidine derivative has the advantages of high atom economy, more complex and diverse structure and certain application prospect.

Access to Benzoxazepines and Fully Substituted Indoles via HDDA Coupling

The HDDA-derived benzyne intermediate was captured by oxazolines based on the addition reaction of benzyne to the Ca?N double bond. Benzoxazepine derivatives, fused benzoxazepine derivatives, and fully substituted indoles are synthesized in one step. The reaction does not require any catalyst or additives. Possible reaction mechanisms are presented.

Phenanthrenes/dihydrophenanthrenes: The selectivity controlled by different benzynes and allenes

A method for the intermolecular annulation of benzynes with allenes is disclosed. This protocol utilized allenes as an unconventional diene component for the selective synthesis of phenanthrenes and dihydrophenanthrenes under the control of different benzyne precursors, featuring high atom-economy and good functional group compatibility. Density functional theory (DFT) calculations reveal that different migratory routes of the aromatic C-H bond are crucial for the observed selectivity. This journal is

Multi-[...] ether derivatives and its preparation method (by machine translation)

The invention relates to the field of organic synthesis, and especially relates to a multi-[...] ether derivatives and its preparation method. The multi-[...] ether derivatives to the ordinary selenide derivatives is the existence of multi-ring, its structure is more complex, in the chemical industry, in clinical medicine also will show more extensive use prospect. In the method for preparing the oxygen free system, the two alkyne class compound, aryl alkyne bromine, anhydrous acetonitrile, transition metal catalyst and organic alkali mixing and reaction intermediates. In the 115 - 125 °C conditions, the intermediate, diphenyl diselenides and toluene mixing and reaction. Preparation method overcomes the reaction route in the past is too long, the substrate and the harsh reaction conditions, substituted functional group extends the limited and the like. (by machine translation)

A isoquinoline [...] derivative and its preparation method

The present invention provides a kind of isoquinoline [...] derivative and its preparation method, the four-alkyne apperception compound in toluene in the reaction with the different kuikui tong, get the isoquinoline [...] derivatives. Compared with the prior art, the present invention provides a new isoquinoline indenone preparation method, generating a series of new isoquinoline [...] derivatives. Synthesis of isoquinoline [...] derivative has high atom economy, the structure is more complex, has a certain application prospect.

Dodecahydrobenzodiindanophenanthrene derivatives and synthesis method thereof

The invention discloses dodecahydrobenzodiindanophenanthrene derivatives and a synthesis method thereof. Compared with the prior art, the invention provides a series of novel benzodiindanophenanthrenederivatives. Compared with the ordinary benzodiindanophenanthrene derivative, the benzodiindanophenanthrene derivatives prepared by the synthesis method provided by the invention have the advantagesas follows: due to existence of multiple rings, the benzodiindanophenanthrene derivatives are more complex and diverse in structure; the benzodiindanophenanthrene derivatives can be prepared into a variety of medicines, can be applied to synthetic resin, plant growth hormones, vat dyes, tanning materials and the like, and also show a brighter application prospect in chemical production; in addition, a preparation method provided by the invention is simple, convenient, short in reaction time and high in efficiency.

Fused naphthalene nucleus compounds and preparation method thereof

The invention discloses fused naphthalene nucleus compounds and a preparation method thereof. Compared with the prior art, the invention provides a brand-new synthetic method for multi-substituted naphthalene derivatives to generate a series of new naphthalene derivatives. Compared with other naphthalene derivatives, the naphthalene derivatives prepared by the invention comprise more nucleuses, are more complex and diverse in structure, and show wider application and prospects in chemical production and clinical medicine.

Convenient one-step construction of yne-functionalized aryl halides through domino cyclization from tetraynes

An efficient method for the construction of fused yne-substituted aryl halides by reaction of unactivated linear tetraynes with allyl halides via domino C-C coupling and formation of C-X bonds in the presence of Pd(OAc) 2/PPh3 was de