157731-16-3

Upstream product

• 107-11-9 1-amino-2-propene 
• 27825-20-3 3-hydroxypyrazine-2-carboxylic acid methyl ester 
• 157731-12-9 Methyl 2-(triphenylphosphoranylidene)aminopyrazine-3-carboxylate 
• 174507-20-1 Methyl tetrazolo<1,5-a>pyrazine-4-carboxylate 
• 27825-21-4 3-chloropyrazine-2-carboxylic acid methyl ester 
• 16298-03-6 Methyl 3-amino-2-pyrazinecarboxylate 

Relevant academic research and scientific papers

Methyl 3-(triphenylphosphoranylideneamino)pyrazine-2-carboxylate: Synthesis, crystal structure and use in pteridin-4(3H)-ones synthesis

The title iminophosphorane 6 has been prepared from methyl 3-aminopyrazine-2-carboxylate 1 by a modified Kirsanov method using a triphenylphosphine-hexachloroethane-triethylamine system. The crystal structure of 6 illustrated an iminophosphorane function (N=P bond). 2,3-Disubstituted pteridin-4(3H)-ones were obtained in a one-pot reaction of 6 with isocyanates, followed by heterocyclization on addition of alcohols or amines.