15776-48-4

Basic information

• Product Name: N10-Pivaloyl tryptamine
• Synonyms: N10-Pivaloyl tryptamine
• CAS NO: 15776-48-4
• Molecular Formula: C₁₅H₂₀N₂O
• Molecular Weight: 244.3321
• Mol File: 15776-48-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 138 °C
• Boiling Point: 483.7±28.0 °C(Predicted)
• Appearance: /
• Density: 1.094±0.06 g/cm3(Predicted)
• PKA: 16.48±0.46(Predicted)
• CAS DataBase Reference: N10-Pivaloyl tryptamine(CAS DataBase Reference)
• NIST Chemistry Reference: N10-Pivaloyl tryptamine(15776-48-4)
• EPA Substance Registry System: N10-Pivaloyl tryptamine(15776-48-4)

Safety Data

• Hazardous Substances Data: 15776-48-4(Hazardous Substances Data)

Upstream product

• 61-54-1 tryptamine 
• 3282-30-2 pivaloyl chloride 

Relevant articles and documents

Synthesis, activity, and QSAR studies of tryptamine derivatives on third-instar larvae of aedes aegypti linn

Special attention has been given to the mosquito Aedes aegypti Linn. (Diptera: Culicidae) owing to numerous dengue epidemic outbreaks worldwide. Failure to control vector spreading is accounted for unorganized urban growth and resistance to larvicides and insecticides. Therefore, researchers are currently searching for new and more efficient larvicides and insecticides to aid dengue control measures. Triptamine is known to affect insect behavior, development, and physiology. Expression of this compound in plants has reduced the growth rate of herbivore insects. In view of these facts, it was of our interest to synthesize triptamine amide derivatives as potential larvicides against Ae. aegypti, establishing a Structure-Activity Relationship. Eleven amide derivatives of triptamine were synthesized, characterized, and evaluated for their larvicidal activity against third-instar Ae. aegypti larvae. N-(2-(1H-indol-3-yl)ethyl)-2,2,2-trichloroacetamide exhibited the highest overall larvicidal potency, while N-(2-(1H-Indol-3-yl)ethyl) acetamide displayed the lowest larvicidal potency. A regression equation correlating the larvicidal activity with Log P was obtained. We have found a clear relationship between the larvicidal activity of non-chlorinated compounds and Log P. Analysis of the relationship between Log P and larvicidal activity against Ae. aegypti may be useful in the evaluation of potential larvicidal compounds.

Catalytic polymer-supported potassium thiophenolate in methanol as a method for the removal of ester, amide, and thioacetate protecting groups

Polymer-supported potassium thiophenolate to remove ester, activated amide, and thioacetate protecting groups catalytically in the presence of methanol is reported.