157770-63-3

Upstream product

• 157770-61-1 (4R)-4-methoxycarbonyl-4-methyl-2-cinnamyl-Δ²-thiazoline 
• 4360-47-8 cinnamonitrile 
• 157770-62-2 (4R)-4-methyl-4-carboxamide-2-cinnamyl-Δ²-thiazoline 

Downstream Products

• 157770-69-9 (4S)-4-methyl-4'<2'(4'S)-4'-methyl-4'(2''-(4''R)-4''-methyl-4''-(2'''-(4'''-methoxycarbonyl-5'''-methyl)oxazole)-Δ²-thiazoline)-Δ²-thiazoline>-2-cinnamyl-Δ²-thiazoline 
• 165054-77-3 (4S)-4-methyl-4-<2'(4'S)-4'-carboxamide-4'-methyl-Δ²-thiazoline>-2-cinnamyl-Δ²-thiazoline 
• 157770-59-7 (4S)-4-methyl-4-<2'(4'R)-4'-nitrile-4'-methyl-Δ²-thiazoline>-2-cinnamyl-Δ²-thiazoline 
• 138667-71-7 (-)-Thiangazole 
• 157770-64-4 (4S)-4-methyl-4-<2'(4'R)-4'-methoxycarbonyl-4'-methyl-Δ²-thiazoline>-2-cinnamyl-Δ²-thiazoline 

Relevant academic research and scientific papers

Total synthesis of thiangazole, a novel naturally occurring HIV-1 inhibitor from Polyangium sp

The total synthesis of the cinnamyl-oxazole substituted tris-thiazoline containing metabolite (-)-thiangazole (1) is described. The synthesis is based on elaboration of the R-2-methylcysteine derived bis-thiazoline nitrile (5) and oxazole (6) intermediate

Total synthesis of thiangazole, a novel inhibitor of HIV-1 from Polyangium sp

A concise total synthesis of the cinnamyl-oxazole substituted tris- thiazoline containing metabolite thiangazole 1 is described.