1577989-85-5

Upstream product

• 1577989-36-6 (R)-phenyl-2-(6-bromo-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)acetate 

Downstream Products

• 1577989-89-9 (R)-8-bromo-5-(4-methoxybenzyl)-9b-(trifluoromethyl)-5,9b-dihydro-1H-azeto[1,2-c]quinazolin-4(2H)-one 

Relevant academic research and scientific papers

Highly enantioselective decarboxylative Mannich reaction of malonic acid half oxyesters with cyclic trifluoromethyl ketimines: Synthesis of β-amino esters and anti-HIV drug DPC 083

An organocatalytic enantioselective decarboxylative Mannich reaction of malonic acid half oxyesters with cyclic ketimines was developed for the preparation of enantioenriched β-amino esters with a quaternary stereogenic center and the anti-HIV drug DPC 083 (see scheme). Copyright