1578-56-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluorovaleric acid is used as a synthetic building block for the development of pharmaceuticals, contributing to the creation of new drugs with improved properties, such as enhanced efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Fluorovaleric acid serves as a key intermediate in the synthesis of agrochemicals, aiding in the production of more effective and targeted pesticides and other agricultural chemicals.
Used in Specialty Chemicals Industry:
2-Fluorovaleric acid is utilized as a precursor in the synthesis of specialty chemicals, which are high-value compounds used in various applications, such as coatings, adhesives, and sealants.
Used in Flavors and Fragrances Industry:
2-Fluorovaleric acid is employed in the production of flavors and fragrances, enhancing the sensory properties of various consumer products, such as food, beverages, and cosmetics, by imparting unique and desirable scents and tastes.

InChI:InChI=1/C5H9FO2/c1-2-3-4(6)5(7)8/h4H,2-3H2,1H3,(H,7,8)

Upstream product

• 109-52-4 valeric acid 
• 88945-70-4 ethyl 2-hydroxy-n-valerate 
• 615-83-8 2-bromo-pentanoic acid ethyl ester 
• 816-26-2 ethyl 2-fluoropentanoate 
• 761-80-8 2-Fluor-valeriansaeurenitril 
• 1578-76-3 diethyl 2-propyl-2-fluoromalonate 

Downstream Products

• 13031-21-5 2-Fluor-valeriansaeure-phenylester 
• 816-26-2 ethyl 2-fluoropentanoate 

Relevant academic research and scientific papers

SARTAN ANALOGUE

The invention concerns a sartan analogue on basis of a sartan which sartan comprises an alkyl group or an alkoxy group, wherein the sartan analogue only differs from the sartan by a replacement of the alkyl group or the alkoxy group or replacement of a methyl residue or a hydrogen residue of the alkyl group or of the alkoxy group by a fluorine atom.

18F-Labeled Derivatives of Irbesartan for Angiotensin II Receptor PET Imaging

The renin angiotensin aldosterone system (RAAS) is a hormonal cascade involved in the regulation of blood pressure and electrolyte balance, and represents a common target for the treatment of various diseases including hypertension, heart failure, and diabetes. Herein we present a novel 18F-labeled derivative of the drug irbesartan, one of the most prescribed angiotensin II type 1 receptor (AT1R) antagonists, for in vivo positron emission tomography (PET). This allows the in vivo measurement of AT1R expression, and thus the evaluation of functional changes in its expression under pathophysiological conditions. We followed various synthetic approaches optimized for the introduction of fluorine into different positions of the aliphatic side chain of irbesartan. Radioligand binding studies revealed that fluorine atoms at specified positions (α-position (IC50=6.6 nm) and δ-position (IC50=8.5 nm) of the aliphatic side chain) do not alter the binding properties of irbesartan (IC50=1.6 nm). After successful radiolabeling with fluorine-18 in a radiochemical yield of 11 %, we observed high renal uptake in healthy rats and pigs, which could be decreased by pretreatment with the parent compound irbesartan.

Studies of a diastereoselective electrophilic fluorination reaction employing a cryo-flow reactor

The application of meso-scale flow chemistry in research laboratories continues to increase. Here, we report on the use of a modular cryo-flow device as applied to a diastereoselective fluorination process. The reactor can be incorporated into existing flow chemistry setups to permit continuous processing at low temperatures without recourse to cryogenic consumables. Georg Thieme Verlag Stuttgart. New York.