88945-70-4

Basic information

• Product Name: (S)-Ethyl-2-hydroxypentanoate
• Synonyms: (S)-Ethyl-2-hydroxypentanoate
• CAS NO: 88945-70-4
• Molecular Formula: C₇H₁₄O₃
• Molecular Weight: 146.185
• Mol File: 88945-70-4.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-Ethyl-2-hydroxypentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-Ethyl-2-hydroxypentanoate(88945-70-4)
• EPA Substance Registry System: (S)-Ethyl-2-hydroxypentanoate(88945-70-4)

Safety Data

• Hazardous Substances Data: 88945-70-4(Hazardous Substances Data)

Usage

General Description

(S)-Ethyl-2-hydroxypentanoate, also known as ethyl-2-hydroxyvalerate, is a chemical compound with the molecular formula C7H14O3. It is an ester, specifically an ethyl ester, of 2-hydroxypentanoic acid. (S)-Ethyl-2-hydroxypentanoate is commonly used as a flavoring agent in the food and beverage industry, adding a sweet and fruity aroma to various products. It is also employed in the manufacturing of perfumes and fragrances due to its pleasant scent. Additionally, (S)-Ethyl-2-hydroxypentanoate can be used as a chemical intermediate in the synthesis of other compounds. Overall, this chemical serves a variety of purposes in different industries due to its unique properties and applications.

Upstream product

• 64-17-5 ethanol 
• 617-31-2 2-hydroxyvaleric acid 
• 74-90-8 hydrogen cyanide 
• 123-72-8 butyraldehyde 
• 50461-74-0 ethyl 2-oxovalerate 
• 75-03-6 ethyl iodide 
• 88945-70-4 ethyl 2-hydroxy-n-valerate 
• 117-34-0 2,2-diphenylacetic acid 
• 2450-71-7 Propargylamine 
• 615-83-8 2-bromo-pentanoic acid ethyl ester 
• 924-44-7 glyoxylic acid ethyl ester 
• 17745-45-8 propylboronic acid 
• 584-93-0 2-Bromovaleric acid 
• 5699-72-9 1-Cyanobutanol 

Downstream Products

• 54639-21-3 3-phenyl-5-propyl-oxazolidine-2,4-dione 
• 1003855-66-0 2-hydroxy-valeric acid anilide 
• 1208982-46-0 ethyl (R)-2-(diphenylacetyloxy)pentanoate 
• 1208982-47-1 ethyl (S)-2-(diphenylacetyloxy)pentanoate 
• 115626-59-0 ethyl (2S)-2-hydroxypentanoate 
• 1578-56-9 2-fluoropentanoic acid 
• 816-26-2 ethyl 2-fluoropentanoate 
• 5343-92-0 1,2-pentanediol 
• 97915-40-7 (5E,7Z,13E)-5,7,13-Pentadecatriene-9,11-diyn-4-ol 
• 1448338-50-8 di(1-naphthyl)methyl (S)-2-[(1,1'-biphenyl)-2-yloxy]pentanoate 
• 1448338-52-0 (R)-2-[(1,1'-biphenyl)-2-yloxy]pentanoic acid 
• 6302-57-4 5-propyl-oxazolidine-2,4-dione 
• 109785-12-8 (S)-5-tert-Butyl-3-[(S)-2-((S)-1-ethoxycarbonyl-butylamino)-propionyl]-2,3-dihydro-[1,3,4]thiadiazole-2-carboxylic acid benzyl ester 
• 109715-02-8 (R)-5-tert-Butyl-3-[(S)-2-((S)-1-ethoxycarbonyl-butylamino)-propionyl]-2,3-dihydro-[1,3,4]thiadiazole-2-carboxylic acid benzyl ester 

Relevant articles and documents

Asymmetric Synthesis of N-Substituted α-Amino Esters from α-Ketoesters via Imine Reductase-Catalyzed Reductive Amination

N-Substituted α-amino esters are widely used as chiral intermediates in a range of pharmaceuticals. Here we report the enantioselective biocatalyic synthesis of N-substituted α-amino esters through the direct reductive coupling of α-ketoesters and amines employing sequence diverse metagenomic imine reductases (IREDs). Both enantiomers of N-substituted α-amino esters were obtained with high conversion and excellent enantioselectivity under mild reaction conditions. In addition >20 different preparative scale transformations were performed highlighting the scalability of this system.

A method for synthesis of 1, 2 - pentanediol (by machine translation)

The invention relates to the field of organic synthetic technology, in particular to a 1, 2 - pentanediol synthetic method, comprises the following steps: (1) heating the raw material-butyraldehyde, adjusting the pH after adding the hydrocyanic acid, obtained by the reaction of 2 - hydroxy pentanonitrile; (2) taking step (1) in 2 - hydroxy pentanonitrile, adding an alcohol as a solvent to stir and mix, add water to stir and mix, hydrogen chloride gas, in 5 °C the following reaction under the condition for a period of time, to continue the reaction temperature, after the reaction product after the neutralization reaction, centrifugal separation, obtained after the distillation is 2 - hydroxy valeric acid ester compound; (3) heating the step (2) in 2 - hydroxy valeric acid ester compound, under the effects of catalyst after hydrogenation reaction to obtain the 1, 2 - pentanediol. Using the synthesis method of the invention, the 1, 2 - pentanediol yield, and reduces the production cost. (by machine translation)

Expeditious and novel synthesis of α-hydroxyesters via rhodium-NHC catalyzed arylation of ethyl glyoxalate

The rhodium-NHC catalyzed arylation reaction of ethyl glyoxalate with aryl and alkyl boronic acids provides an efficient method for the synthesis of α-hydroxyesters. A wide range of α-hydroxyesters (up to 12) were prepared in good to excellent yields. KOtBu was the base of choice, along with tert-amyl alcohol as the solvent. As far as we are aware, this is the first report of this catalytic arylation, using rhodium-NHC catalysts with this specific substrate type.