1578244-93-5

Basic information

• Product Name: 3-methoxy-2-((2-((2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)amino)propan-1-ol
• Synonyms: 3-methoxy-2-((2-((2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)amino)propan-1-ol
• CAS NO: 1578244-93-5
• Molecular Weight: 435.486
• Mol File: 1578244-93-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-methoxy-2-((2-((2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)amino)propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methoxy-2-((2-((2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)amino)propan-1-ol(1578244-93-5)
• EPA Substance Registry System: 3-methoxy-2-((2-((2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)amino)propan-1-ol(1578244-93-5)

Safety Data

• Hazardous Substances Data: 1578244-93-5(Hazardous Substances Data)

Upstream product

• 1578246-27-1 N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)formamide 
• 1578245-93-8 methyl 5-[(E)-2-ethoxyethenyl]-2-(methylsulfanyl)pyrimidine-4-carboxylate 
• 50593-91-4 methyl 5-bromo-2-(methylsulfanyl)pyrimidine-4-carboxylate 
• 50593-92-5 5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid 
• 1578244-55-9 8-chloro-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]-pyrimidin-2-amine 
• 148278-96-0 2-amino-3-methoxypropan-1-ol 
• 1578246-63-5 8-chloro-2-(methylsulfonyl)pyrido[3,4-d]pyrimidine 
• 1578245-95-0 8-chloro-2-(methylsulfanyl)pyrido[3,4-d]pyrimidine 
• 1578245-94-9 2-(methylsulfanyl)-7H,8H-pyrido[3,4-d]pyrimidin-8-one 

Relevant articles and documents

INHIBITOR COMPOUNDS

The present invention relates to compounds of formula (I), wherein R, R, Ar, W, X and Z are all as defined herein. The compounds of the present invention are known to inhibit the spindle checkpoint function of Monospindle 1 (Mps1 - also known as TTK) kinases either directly or indirectly via interaction with the Mps1 kinase itself. In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them