15783-73-0

Upstream product

• 15897-55-9 5-Amino-3-(p-chlorophenyl)isoxazole-4-carboxamide 
• 122-51-0 orthoformic acid triethyl ester 
• 74903-80-3 (Z)-N-hydroxy-4-chloro-benzenecarboximidoyl chloride 
• 104-88-1 4-chlorobenzaldehyde 
• 3717-24-6 4-chlorobenzaldehyde oxime 
• 77287-34-4 formamide 
• 98949-16-7 5-amino-3-(4-chlorophenyl)isoxazole-4-carbonitrile 

Downstream Products

• 119898-12-3 [3-(4-Chloro-phenyl)-isoxazolo[5,4-d]pyrimidin-4-yloxy]-acetic acid ethyl ester 
• 119898-20-3 C₂₀H₁₄BrClN₆O₃S 
• 119898-26-9 (4-Bromo-phenyl)-{5-[3-(4-chloro-phenyl)-isoxazolo[5,4-d]pyrimidin-4-yloxymethyl]-[1,3,4]thiadiazol-2-yl}-amine 
• 119898-32-7 (4-Bromo-phenyl)-{5-[3-(4-chloro-phenyl)-isoxazolo[5,4-d]pyrimidin-4-yloxymethyl]-[1,3,4]oxadiazol-2-yl}-amine 
• 119898-38-3 4-(4-Bromo-phenyl)-5-[3-(4-chloro-phenyl)-isoxazolo[5,4-d]pyrimidin-4-yloxymethyl]-4H-[1,2,4]triazole-3-thiol 
• 119898-19-0 C₂₁H₁₇ClN₆O₃S 
• 119898-25-8 {5-[3-(4-Chloro-phenyl)-isoxazolo[5,4-d]pyrimidin-4-yloxymethyl]-[1,3,4]thiadiazol-2-yl}-p-tolyl-amine 
• 119898-31-6 {5-[3-(4-Chloro-phenyl)-isoxazolo[5,4-d]pyrimidin-4-yloxymethyl]-[1,3,4]oxadiazol-2-yl}-p-tolyl-amine 
• 119898-37-2 5-[3-(4-Chloro-phenyl)-isoxazolo[5,4-d]pyrimidin-4-yloxymethyl]-4-p-tolyl-4H-[1,2,4]triazole-3-thiol 
• 119898-42-9 5-[3-(4-Chloro-phenyl)-isoxazolo[5,4-d]pyrimidin-4-yloxymethyl]-[1,3,4]oxadiazole-2-thiol 
• 119898-15-6 [3-(4-Chloro-phenyl)-isoxazolo[5,4-d]pyrimidin-4-yloxy]-acetic acid hydrazide 

Relevant academic research and scientific papers

HETEROAROMATIC NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed herein, in part, are heteroaromatic compounds and methods of use in treating neuropsychiatric disorders, e.g., schizophrenia and major depressive disorder. Pharmaceutical compositions and methods of making heteroaromatic compounds are provided. The compounds are contemplated modulate the NMDA receptor.

Isoxazolopyrimidines as novel F508-CFTR correctors

Using a cell-based high-throughput screen, we identified isoxazolo[5,4-d]pyrimidines as novel small-molecule correctors of the cystic fibrosis mutant protein F508-CFTR. 22 Isoxazolo[5,4-d]pyrimidine analogues were synthesized and tested. Synthesis of the