15897-55-9Relevant academic research and scientific papers
Isoxazolopyrimidines as novel F508-CFTR correctors
Yu, Gui Jun,Yang, Baoxue,Verkman,Kurth, Mark J.
, p. 1063 - 1066 (2010)
Using a cell-based high-throughput screen, we identified isoxazolo[5,4-d]pyrimidines as novel small-molecule correctors of the cystic fibrosis mutant protein F508-CFTR. 22 Isoxazolo[5,4-d]pyrimidine analogues were synthesized and tested. Synthesis of the
