15788-99-5

Upstream product

• 19438-10-9 methyl 3-hydroxybenzoate 
• 141-43-5 ethanolamine 

Downstream Products

• 15504-64-0 3-Hydroxy-N-(2-hydroxy-ethyl)-2,4,6-triiodo-benzamide 
• 90141-21-2 3-(4,5-dihydro-1,3-oxazol-2-yl)phenol 
• 15504-82-2 [3-(2-Hydroxy-ethylcarbamoyl)-2,4,6-triiodo-phenoxy]-phenyl-acetic acid 
• 15504-88-8 2-[3-(2-Hydroxy-ethylcarbamoyl)-2,4,6-triiodo-phenoxy]-hexanoic acid 
• 15504-56-0 2-[3-(2-Hydroxy-ethylcarbamoyl)-2,4,6-triiodo-phenoxy]-butyric acid 
• 15504-95-7 4-[3-(2-Hydroxy-ethylcarbamoyl)-2,4,6-triiodo-phenoxy]-butyric acid 

Relevant academic research and scientific papers

Three isomeric forms of hydroxyphenyl-2-oxazoline: 2-(2-hydroxyphenyl)-2- oxazoline, 2-(3-hydroxyphenyl)-2-oxazoline and 2-(4-hydroxyphenyl)-2-oxazoline

Crystal structures are reported for three isomeric compounds, namely 2-(2-hydroxyphenyl)-2-oxazoline, (I), 2-(3-hydroxyphenyl)-2-oxazoline, (II), and 2-(4-hydroxyphenyl)-2-oxazoline, (III), all C9H9NO 2 [systematic names: 2-(4,5-dihydro-1,3-oxazol-2-yl)phenol, (I), 3-(4,5-dihydro-1,3-oxazol-2-yl)phenol, (II), and 4-(4,5-dihydro-1,3-oxazol-2-yl) phenol, (III)]. In these compounds, the deviation from coplanarity of the oxazoline and benzene rings is dependent on the position of the hydroxy group on the benzene ring. The coplanar arrangement in (I) is stabilized by a strong intramolecular O-H...N hydrogen bond. Surprisingly, the 2-oxazoline ring in molecule B of (II) adopts a 3T4 (C2T C3) conformation, while the 2-oxazoline ring in molecule A, as well as that in (I) and (III), is nearly planar, as expected. Tetramers of molecules of (II) are formed and they are bound together via weak C-H...N hydrogen bonds. In (III), strong intermolecular O-H...N hydrogen bonds and weak intramolecular C-H...O hydrogen bonds lead to the formation of an infinite chain of molecules perpendicular to the b direction. This paper also reports a theoretical investigation of hydrogen bonds, based on density functional theory (DFT) employing periodic boundary conditions.

Di-heterocyclic compounds and their use as antiviral agents

Compounds of the formulas: STR1 wherein Het is an oxazole or oxazine moiety; X is O, S or SO, n is an integer from 3 to 9, Y is an aliphatic bridge; and the various R groups represent hydrogen or various substituents as described herein, are useful as antiviral agents, especially against picornaviruses. N-(Chloroalkyl)amide intermediates for the compounds of Formula I are also active as antiviral agents. Related compounds outside the scope of the above formulas are also disclosed.