157886-79-8

Upstream product

• 125316-33-8 3-<3-(2,6,6-trimethyl-2-cyclohexen-1-yl)-1-methyl-2-propenyl>-5-<(E)-3-(acetyloxy)-1-methyl-1-propenyl>-isoxazole 
• 130285-78-8 (E)-2-Methyl-4-(2,6,6-trimethyl-cyclohex-1-enyl)-but-3-enal oxime 
• 35272-88-9 trans-1-acetoxy-3-methyl-2-penten-4-yne 
• 98-88-4 benzoyl chloride 
• 157886-78-7 (+/-)-(E,E,E)-9-(acetyloxy)-4-amino-3,7-dimethyl-1-<2,6,6-trimethyl-1-cyclohexen-1-yl>-1,4,7-nonatrien-6-one 

Downstream Products

• 96707-41-4 (+/-)-(E,E,E)-9,10-dihydro-10-hydroxy-retinol 15-acetate 
• 120591-27-7 (+/-)-(E,E,E)-9-(acetyloxy)-3,7-dimethyl-1-<2,6,6-trimethyl-1-cyclohexen-1-yl>-1,5,7-nonatrien-4-one 

Relevant academic research and scientific papers

Application of [3+2] nitrile oxide cycloaddition chemistry to the construction of retinoid skeleton and to a new formal synthesis of (±)-ascofuranone and geiparvarin

A flexible approach to the construction of the C-20 retinoid carbon skeleton involving the intermolecular [3+2] cycloaddition of the nitrile oxide derived from a C-14 aldehyde component with both a C-6 diene or enyne dipolarophiles, followed by Mo(CO)6-promoted ring opening of the derived 3,5-disubstituted-isoxazoline or -isoxazole ring systems, has been accomplished. The same strategy has been also successfully applied as a tool for the crucial carbon-carbon bond forming step to the formal synthesis of (±)-ascofuranone and to a new synthesis of geiparvarin.