157904-53-5Relevant articles and documents
An improved synthesis of substituted indan-1-carboxylic acid
Gan, Zongjie,Zhang, Di,Cao, Zhe,Xu, Yungen
, p. 317 - 319 (2011)
Substituted indan-1-carboxylic acid compounds have been prepared by clyclisation of the phenyl succinic acid and reduction of the indanon-1-carboxylic acid with triethylsilane in trifluoracetic acid.
Synthesis of 5, 6-dichloroindan-1-acids and their tetrazolyl derivatives as analgesic and anti-inflammatory agents
Pal, Rajib Kumar,Yasmin, Hasina,Nahar, Lutfun,Datta, Bidyut Kanti,Kundu, Joydeb Kumar,Bachar, Sitesh Chandra,Chowdhury, Abul Kalam Azad,Sarker, Satyajit Dey
, p. 874 - 882,9 (2020/08/31)
Indan derivatives, namely, 5-(5′,6′-dichloroindan-1′-yl)- tetrazole (12a) and 5-(5′,6′-dichloroindan-1′-yl)- methyltetrazole (12b), were synthesized conveniently from 5,6-dichloroindan-1- carboxylic acid (9a) and 5,6- dichloroindan-1-acetic acid (9b), respectively, as potential analgesic and anti-inflammatory agents. The analgesic and anti-inflammatory properties of 9a, 9b, 12a and 12b were evaluated by the acetic acid induced writhing in Swiss albino mice and the carrageenan-induced rat paw edema models, respectively. Compounds 9a and 12a exhibited significant analgesic activity with the doses of 50 and 100 mg/kg body weight, comparable to that of the positive controls, phenylbutazone, indomethacin and aminopyrine. The anti-inflammatory potencies of 9a and 12a were also comparable to that of the positive control, phenylbutazone. Compounds 9b and 12b showed analgesic and anti-inflammatory activities, but were weaker than that of compounds 9a and 12a.
