15791-90-9

Basic information

• Product Name: 2,5-DIHYDROXYBENZOHYDRAZIDE
• Synonyms: 2,5-DIHYDROXYBENZOHYDRAZIDE;2,5-Dihydroxybenzhydrazide;2,5-dihydroxybenzohydrazide(SALTDATA: FREE);Benzoic acid, 2,5-dihydroxy-, hydrazide
• CAS NO: 15791-90-9
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.15
• Mol File: 15791-90-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 209-210 °C
• Appearance: /
• Density: 1.477g/cm³
• Refractive Index: 1.67
• PKA: 9.15±0.43(Predicted)
• CAS DataBase Reference: 2,5-DIHYDROXYBENZOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIHYDROXYBENZOHYDRAZIDE(15791-90-9)
• EPA Substance Registry System: 2,5-DIHYDROXYBENZOHYDRAZIDE(15791-90-9)

Safety Data

• Hazardous Substances Data: 15791-90-9(Hazardous Substances Data)

Usage

General Description

2,5-Dihydroxybenzohydrazide is a chemical compound with the molecular formula C7H8N2O3. It is commonly known as DBH and is a white crystalline powder that is sparingly soluble in water. 2,5-DIHYDROXYBENZOHYDRAZIDE is used in the production of dyes, pharmaceuticals, and as a intermediate in organic synthesis. It has antioxidant properties and is also utilized as a reagent in the determination of certain metals in analytical chemistry. Additionally, 2,5-dihydroxybenzohydrazide has shown potential for use in the development of antiviral and antibacterial agents. Overall, this chemical has a variety of applications in different industries, making it a valuable compound in the field of chemistry.

InChI:InChI=1/C7H8N2O3/c8-9-7(12)5-3-4(10)1-2-6(5)11/h1-3,10-11H,8H2,(H,9,12)

Upstream product

• 490-79-9 2,5-dihydroxybenzoic acid. 
• 3943-91-7 ethyl 2,5-dihydroxybenzoate 
• 2150-46-1 Methyl 2,5-dihydroxybenzoate 

Downstream Products

• 220042-06-8 N-[N'-(2,5-Dihydroxy-benzoyl)-hydrazinocarbothioyl]-benzamide 
• 19949-23-6 2-(5-amino-1,3,4-oxadiazol-2-yl)benzene-1,4-diol 

Relevant articles and documents

Structure based discovery of novel hexokinase 2 inhibitors

Hexokinase 2 (HK2) is over-expressed in most of human cancers and has been proved to be a promising target for cancer therapy. In this study, based on the structure of HK2, we screened over 6 millions of compounds to obtain the lead. A total of 26 (E)-N′-(2,3,4-trihydroxybenzylidene) arylhydrazide derivatives were then designed, synthesized, and evaluated for their HK2 enzyme activity and IC50 values against two cancer cell lines. Most of the 26 target compounds showed excellently in vitro activity. Among them, compound 3j showed the strongest inhibitory effects on HK2 enzyme activity with an IC50 of 0.53 ± 0.13 μM and exhibited the most potent growth inhibition against SW480 cells with an IC50 of 7.13 ± 1.12 μM, which deserves further studies.

Synthesis and evaluation of new phenolic derivatives as antimicrobial and antioxidant agents

Abstract: New phenolic derivatives bearing hydrazine and 1,3,4-oxadiazole moieties were synthesized and evaluated for their in vitro antimicrobial and antioxidant activities. Most of the compounds revealed pronounced activity against Pseudomonas aeruginos