157929-97-0

Upstream product

• 64809-29-6 methyl 3-hydroxy-2-methylpropanoate 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 820963-51-7 3-(tert-butyldiphenylsilanyloxy)-2-methylpropionic acid 
• 1352039-09-8 (E)-methyl 2,2,6,13-tetramethyl-9-methylene-7,12,15-trioxo-3,3-diphenyl-4-oxa-8,13,16-triaza-3-silaoctadec-10-en-18-oate 
• 1352039-08-7 3-((tert-butyldiphenylsilyl)oxy)-2-methyl-N-(3-oxoprop-1-en-2-yl)propanamide 
• 152648-22-1 3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-propionamide 

Relevant academic research and scientific papers

Intramolecular Amidoalkylation of Chiral Iminium Ions: Stereoselective Synthesis of syn-1,3-Aminoalcohols

The intramolecular Hosomi-Sakurai reaction of 3-siloxybutaniminium salts exhibited a syn selectivity of up to 51:1, while the same type of reaction of 2-methyl-3-siloxypropaniminium salts showed up to 290:1 syn selectivity.

A concise route to the macrocyclic core of the rakicidins

An efficient synthesis of the macrolactone core of the rakicidins is described. The rakicidins are cytotoxic lipopeptides with interesting cancer cell selectivities including HIF-1-independent hypoxia-selective cytotoxicity and anti-invasive activity. Access to the core may now allow establishment of preliminary SAR and exploration of routes to several members of rakicidins.