1579292-67-3Relevant academic research and scientific papers
Cysteine pseudoprolines for thiol protection and peptide macrocyclization enhancement in fmoc-based solid-phase peptide synthesis
Postma, Tobias M.,Albericio, Fernando
supporting information, p. 1772 - 1775 (2014/04/17)
Contrary to other studies, here we describe cysteine (Cys) pseudoproline-containing peptides with short deprotection times in TFA. The deprotection times fell in the same range as other protecting groups commonly used in SPPS (e.g., 1-3 h). Moreover, when using Cys pseudoprolines as peptide macrocyclization-enhancing moieties a considerable reduction in reaction time was observed compared to a peptide containing trityl protected Cys.
