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50-81-7 Usage

Description

Ascorbic acid, a water-soluble dietary supplement, is consumed by humans more than any other supplement. The name ascorbic means antiscurvy and denotes the ability of ascorbic to combat this disease. Vitamin C is the l-enantiomer of ascorbic acid. Ascorbic acid deficiency in humans results in the body’s inability to synthesize collagen, which is the most abundant protein in vertebrates.

Description

L-Ascorbic acid is a naturally occurring electron donor and therefore serves as a reducing agent.1 It is synthesized from glucose in the liver of most mammalian species, excluding humans, non-human primates, or guinea pigs who must obtain it through dietary consumption. In humans, L-Ascorbic acid acts as an electron donor for eight different enzymes, including those related to collagen hydroxylation, carnitine synthesis (which aids in the generation of adenosine triphosphate), norepinephrine synthesis, tyrosine metabolism, and amidating peptides.2,3,4,5,6 L-Ascorbic acid demonstrates antioxidant activity that may be of some benefit for reducing the risk of developing chronic diseases such as cancer, cardiovascular disease, and cataracts.1

Chemical Properties

White crystals (plates or needles). Soluble in water; slightly soluble in alcohol; insoluble in ether, chloroform, benzene, petroleum ether, oils and fats. Stable to air when dry. One international unit is equivalent to 0.05 milligram of l-ascorbic acid.

Chemical Properties

Ascorbic acid occurs as a white to light-yellow-colored, nonhygroscopic, odorless, crystalline powder or colorless crystals with a sharp, acidic taste. It gradually darkens in color upon exposure to light.

Physical properties

Appearance: white crystal or crystalline powder, and it is odorless and flavors sour. The color changes yellowish when exposed in the air for a long time. Its aqueous solution is acidic reaction. Solubility: vitamin C is soluble in water, slightly soluble in ethanol, and insoluble in chloroform or ether. Melting point: 190–192? °C.? It would decompose when it melts. Specific optical rotation: +20.5 to +21.5°. Ascorbic acid is two-base acid (the pKa is 4.1 and 11.8). It occurs mainly in the form of sodium salt and calcium salt, and its aqueous solution is strongly acidic reaction. Ascorbic acid is a strong reducing agent.

Originator

Ascorbic aci,Natur Product,France

History

Vitamin C is a general term for compounds having ascorbic acid activity, including ascorbic acid, dehydroascorbic acid, and its isomers.The understanding of vitamin C has gone through a long and painful process. Although the relationship between scurvy and stored food is obvious, but the treatments of this disease have been misguided. By 1601, British armed Captain James Lancaster discovered the disease on the ship of the East India Company and regarded the scurvy as “rot,” which could be made tissue alkaline. At the early stage of the nineteenth century, the understanding and treatment of scurvy had developed to a right approach. The exposition of scurvy etiology and metabolic theory took more than a century.By the early stage of the twentieth century, inspired by the animal model of beriberi, researchers in the Christchurch Oslo University discovered one animal that could suffer scurvy accidentally and then established a valuable scurvy animal model. This experiment demonstrated that the extract isolated from lemon had antiscurvy activity. Until 1932, many research groups obtained the anti-scurvy crystal from different plants and identified the crystal as ascorbic acid vitamin C. Next year, the chemical structure of ascorbic acid was elucidated, and then its artificial synthesis was accomplished.

Uses

The starting point for synthesis of vitamin C is the selective of oxidation of the sugar compound D-sorbit to L-sorbose using Acetobacter suboxidans bacteria. L-sorbose is then converted to L-ascorbic acid, better known as vitamin C.

Uses

Sodium, potassium, and calcium salts of ascorbic acids are called ascorbates and are used as food preservatives. To make ascorbic acid fat-soluble, it can be esterified. Esters of ascorbic acid and acids, such as palmitic acid to form ascorbyl palmitate and stearic acid to form ascorbic stearate, are used as antioxidants in food, pharmaceuticals, and cosmetics. Ascorbic acid is also essential in the metabolism of some amino acids. It helps protect cells from free radical damage, helps iron absorption, and is essential for many metabolic processes.

Uses

vitamin C is a well-known anti-oxidant. Its effect on free-radical formation when topically applied to the skin by means of a cream has not been clearly established. The effectiveness of topical applications has been questioned due to vitamin C’s instability (it reacts with water and degrades). Some forms are said to have better stability in water systems. Synthetic analogues such as magnesium ascorbyl phosphate are among those considered more effective, as they tend to be more stable. When evaluating its ability to fight free-radical damage in light of its synergistic effect with vitamin e, vitamin C shines. As vitamin e reacts with a free radical, it, in turn, is damaged by the free radical it is fighting. Vitamin C comes in to repair the free-radical damage in vitamin e, allowing e to continue with its free-radical scavenging duties. Past research has indicated that high concentrations of topically applied vitamin C are photoprotective, and apparently the vitamin preparation used in these studies resisted soap and water, washing, or rubbing for three days. More current research has indicated that vitamin C does add protection against uVB damage when combined with uVB sunscreen chemicals. This would lead one to conclude that in combination with conventional sunscreen agents, vitamin C may allow for longer-lasting, broader sun protection. Again, the synergy between vitamins C and e can yield even better results, as apparently a combination of both provides very good protection from uVB damage. However, vitamin C appears to be significantly better than e at protecting against uVA damage. A further conclusion is that the combination of vitamins C, e, and sunscreen offers greater protection than the sum of the protection offered by any of the three ingredients acting alone. Vitamin C also acts as a collagen biosynthesis regulator. It is known to control intercellular colloidal substances such as collagen, and when formulated into the proper vehicles, can have a skin-lightening effect. Vitamin C is said to be able to help the body fortify against infectious conditions by strengthening the immune system. There is some evidence (although debated) that vitamin C can pass through the layers of the skin and promote healing in tissue damaged by burns or injury. It is found, therefore, in burn ointments and creams used for abrasions. Vitamin C is also popular in anti-aging products. Current studies indicate possible anti-inflammatory properties as well.

Uses

antiscorbutic, antiviral

Uses

analgesic, antipyretic

Uses

Physiological antioxidant. Coenzyme for a number of hydroxylation reactions; required for collagen synthesis. Widely distributed in plants and animals. Inadequate intake results in deficiency syndrome s such as scurvy. Used as antimicrobial and antioxidant in foodstuffs.

Definition

ChEBI: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.

Production Methods

Ascorbic acid is prepared synthetically or extracted from various vegetable sources in which it occurs naturally, such as rose hips, blackcurrants, the juice of citrus fruits, and the ripe fruit of Capsicum annuum L. A common synthetic procedure involves the hydrogenation of D-glucose to D-sorbitol, followed by oxidation using Acetobacter suboxydans to form L-sorbose. A carboxyl group is then added at C1 by air oxidation of the diacetone derivative of Lsorbose and the resulting diacetone-2-keto-L-gulonic acid is converted to L-ascorbic acid by heating with hydrochloric acid.

Production Methods

Ascorbic acid is produced synthetically using the Reichstein process, which has been the standard method of production since the 1930s. The process starts with fermentation followed by chemical synthesis. The first step involves reduction of D-glucose at high temperature into D-sorbitol. D-sorbitol undergoes bacterial fermentation, converting it into L-sorbose. L-sorbose is then reacted with acetone in the presence of concentrated sulfuric acid to produce diacetone-L-sorbose, which is then oxidized with chlorine and sodium hydroxide to produce di-acetone-ketogulonic acid (DAKS). DAKS is then esterified with an acid catalyst and organics to give a gulonic acid methylester. The latter is heated and reacted with alcohol to produce crude ascorbic acid, which is then recrystallized to increase its purity. Since the development of the Reichstein process more than 70 years ago, it has undergone many modifications. In the 1960s, a method developed in China referred to as the two-stage fermentation process used a second fermentation stage of L-sorbose to produce a different intermediate than DAKS called KGA (2-keto-L-gulonic acid), which was then converted into ascorbic acid. The two stage process relies less on hazardous chemicals and requires less energy to convert glucose to ascorbic acid.

Indications

Vitamin C (ascorbic acid) is essential for the maintenance of the ground substance that binds cells together and for the formation and maintenance of collagen.The exact biochemical role it plays in these functions is not known, but it may be related to its ability to act as an oxidation–reduction system.

Manufacturing Process

D-Glucose was reduced to the D-sorbitol with a hydrogen over Ni Raney, then it was turned into the L-sorbose with the acetobacter suboxydans and the hydroxyl groups of L-sorbose were protected with acetone treatment yielded the diaceton-L-sorbose. Subsequent treatment with NaOCl/Raney Ni produced di-O-isopropylidene-2-oxo-L-gulonic acid. Partial hydrolysis with aqueous HCl gave deprotected 2-oxo-L-gulonic acid, which yielded ascorbinic acid by heating with HCl.

Brand name

Ascorbin (Marion Merrell Dow).

Therapeutic Function

Vitamin

General Description

Scurvy (from the French word scorbutus) has been recognized as a disease afflicting mankind for thousands of years. Citrus fruits such as oranges, lemons, and limes were later identified as equally effective treatments. Only within the last 100 years has a deficiency in vitamin C been definitively identified as the cause of scurvy. In 1932, Waugh and King isolated crystalline vitamin C from lemon juice and showed it to be the antiscorbutic factor present in each of these treatments. The structure and chemical formula of vitamin C was identified in 1933 by Hirst et al.Because humans are one of the few animal species that cannot synthesize vitamin C, it has to be available as a dietary component. Dietary sources of ascorbic acid include fruits (especially citrus fruits), vegetables (especially peppers), and potatoes. Although the sources of some commercial products are rose hips and citrus fruits, most ascorbic acid is prepared synthetically.Vitamin C is now commonly referred to as ascorbic acid because of its acidic character and its effectiveness in the treatment and prevention of scorbutus (scurvy). The acidic character is because of the two enolic hydroxyls; the C3 hydroxyl has a pKa value of 4.1, and the C2 hydroxyl has a pKa of 11.6. All biological activities reside in L-ascorbic acid; therefore, all references to vitamin C, ascorbic acid, ascorbate, and their derivatives refer to this form. The monobasic sodium salt is the usual salt form.

General Description

White to very pale yellow crystalline powder with a pleasant sharp acidic taste. Almost odorless.

Air & Water Reactions

May be sensitive to prolonged exposure to air and light. Sensitive to moisture. Soluble in water. Aqueous solutions are oxidized by air in a reaction that is accelerated by alkalis, iron and copper. The rate depends on the pH and on oxygen concentration. Also subject to degradation under anaerobic conditions.

Reactivity Profile

L(+)-Ascorbic acid is a lactone. Reacts as a relatively strong reducing agent and decolorizes many dyes. Forms stable metal salts. Incompatible with oxidizers, dyes, alkalis, iron and copper. Also incompatible with ferric salts and salts of heavy metals, particularly copper, zinc and manganese .

Fire Hazard

Flash point data for L(+)-Ascorbic acid are not available; however, L(+)-Ascorbic acid is probably combustible.

Pharmaceutical Applications

Ascorbic acid is used as an antioxidant in aqueous pharmaceutical formulations at a concentration of 0.01–0.1% w/v. Ascorbic acid has been used to adjust the pH of solutions for injection, and as an adjunct for oral liquids. It is also widely used in foods as an antioxidant. Ascorbic acid has also proven useful as a stabilizing agent in mixed micelles containing tetrazepam.

Biochem/physiol Actions

L-ascorbic acid mainly exhibits antioxidant properties. It protects plants from oxidative stress and mammals from diseases associated with oxidative stress. L-ascorbic acid mainly protects from hydroxyl radicals, superoxide and singlet oxygen. In addition, it also reduces the membrane-linked antioxidant α-tocopherol (oxidised form). L-Ascorbic acid enhances endothelium-dependent vasodilation in various disorders, including diabetes, coronary artery disease, hypertension and chronic heart failure.

Pharmacology

Vitamin C is considered as a classical enzyme cofactor or antioxidant but also as a transition material in metal ion reaction. And all of these functions of vitamin C are related to the property of antioxidation.

Clinical Use

Vitamin C is indicated for the treatment and prevention of known or suspect deficiency. Although scurvy occurs infrequently, it is seen in the elderly, infants, alcoholics, and drug users.Ascorbate can also be used to enhance absorption of dietary nonheme iron or iron supplements. Ascorbic acid (but not the sodium salt) was historically used to acidify the urine as a result of excretion of unchanged ascorbic acid, although this use has fallen into disfavor. Ascorbate also increases iron chelation by deferoxamine, explaining its use in the treatment of iron toxicity.

Clinical Use

Vitamin C is found in fresh fruit and vegetables. It is very water soluble, is readily destroyed by heat, especially in an alkaline medium, and is rapidly oxidized in air. Fruit and vegetables that have been stored in air, cut or bruised, washed, or cooked may have lost much of their vitamin C content. The deficiency disease associated with a lack of ascorbic acid is called scurvy. Early symptoms include malaise and follicular hyperkeratosis. Capillary fragility results in hemorrhages, particularly of the gums. Abnormal bone and tooth development can occur in growing children.The body’s requirement for vitamin C increases during periods of stress, such as pregnancy and lactation.

Side effects

Megavitamin intake of vitamin C may result in diarrhea due to intestinal irritation. Since ascorbic acid is partially metabolized and excreted as oxalate, renal oxalate stones may form in some patients.

Toxicology

L-Ascorbic acid, or vitamin C, is widely present in plants. The structures of ascorbic acid and dehydroascorbic acid are shown in Figure 10.5. Vitamin C is not only an important nutrient but is also used as an antioxidant in various foods. However, it is not soluble in fat and is unstable under basic conditions. Vitamin C reduces cadmium toxicity and excess doses prolong the retention time of an organic mercury compound in a biological system. Overdoses of vitamin C (106 g) induce perspiration, nervous tension, and lowered pulse rate. WHO recommends that daily intake be less than 0.15 mg/kg. Toxicity due to ascorbic acid has not been reported. Although repeated intravenous injections of 80 mg dehydroascorbic acid was reported to be diabetogenic in rats, oral consumption of 1.5 g/day of ascorbic acid for six weeks had no effect on glucose tolerance or glycosuria in 12 normal adult males and produced no change in blood glucose concentrations in 80 diabetics after five days. The same report noted that a 100-mg intravenous dose of dehydroascorbic acid given daily for prolonged periods produced no signs of diabetes. Ascorbic acid is readily oxidized to dehydroascorbic acid, which is reduced by glutathione in blood.

Safety Profile

Moderately toxic by ingestion and intravenous routes. Human systemic effects by intravenous route: blood, changes in tubules (including acute renal failure, acute tubular necrosis). An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

Ascorbic acid is an essential part of the human diet, with 40 mg being the recommended daily dose in the UK and 60 mg in the USA. However, these figures are controversial, with some advocating doses of 150 or 250mg daily. Megadoses of 10 g daily have also been suggested to prevent illness although such large doses are now generally considered to be potentially harmful. The body can absorb about 500 mg of ascorbic acid daily with any excess immediately excreted by the kidneys. Large doses may cause diarrhea or other gastrointestinal disturbances. Damage to the teeth has also been reported. However, no adverse effects have been reported at the levels employed as an antioxidant in foods, beverages, and pharmaceuticals. The WHO has set an acceptable daily intake of ascorbic acid, potassium ascorbate, and sodium ascorbate, as antioxidants in food, at up to 15 mg/kg bodyweight in addition to that naturally present in food. LD50 (mouse, IV): 0.52 g/kg LD50 (mouse, oral): 3.37 g/kg LD50 (rat, oral): 11.9 g/kg

Drug interactions

Potentially hazardous interactions with other drugs None known

Metabolism

Ascorbic acid is reversibly oxidised to dehydroascorbic acid; some is metabolised to ascorbate-2-sulfate, which is inactive, and oxalic acid which are excreted in the urine. Ascorbic acid in excess of the body's needs is also rapidly eliminated unchanged in the urine; this generally occurs with intakes exceeding 100 mg daily.

storage

In powder form, ascorbic acid is relatively stable in air. In the absence of oxygen and other oxidizing agents it is also heat stable. Ascorbic acid is unstable in solution, especially alkaline solution, readily undergoing oxidation on exposure to the air.The oxidation process is accelerated by light and heat and is catalyzed by traces of copper and iron. Ascorbic acid solutions exhibit maximum stability at about pH 5.4. Solutions may be sterilized by filtration. The bulk material should be stored in a well-closed nonmetallic container, protected from light, in a cool, dry place.

Purification Methods

Crystallise it from MeOH/Et2O/pet ether [Herbert et al. J Chem Soc 1270 1933]. [Beilstein 18/5 V 26.]

Toxicity evaluation

Metabolism of ascorbic acid can lead to deposition of oxalate crystals in kidney tissue. Reduction of carcinogenic Cr(VI) by ascorbic acid generates ascorbate–Cr(III)–DNA cross-links that have been linked to mutagenicity and the formation of DNA lesions. Uranyl acetate–ascorbate has also been shown to nick plasmid DNA.

Incompatibilities

Incompatible with alkalis, heavy metal ions, especially copper and iron, oxidizing materials, methenamine, phenylephrine hydrochloride, pyrilamine maleate, salicylamide, sodium nitrite, sodium salicylate, theobromine salicylate, and picotamide. Additionally, ascorbic acid has been found to interfere with certain colorimetric assays by reducing the intensity of the color produced.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations, injections, oral capsules, suspensions, tablets, topical preparations, and suppositories). Included in medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
InChI:InChI=1/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2

50-81-7 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (A0537)  L-Ascorbic Acid  >99.0%(T) 50-81-7 25g 135.00CNY Detail
TCI America (A0537)  L-Ascorbic Acid  >99.0%(T) 50-81-7 500g 520.00CNY Detail
Alfa Aesar (11188)  L-(+)-Ascorbic acid, 98+%    50-81-7 100g 196.0CNY Detail
Alfa Aesar (11188)  L-(+)-Ascorbic acid, 98+%    50-81-7 500g 515.0CNY Detail
Alfa Aesar (11188)  L-(+)-Ascorbic acid, 98+%    50-81-7 2kg 1886.0CNY Detail
Alfa Aesar (A15613)  L-(+)-Ascorbic acid, 99+%    50-81-7 50g 148.0CNY Detail
Alfa Aesar (A15613)  L-(+)-Ascorbic acid, 99+%    50-81-7 100g 178.0CNY Detail
Alfa Aesar (A15613)  L-(+)-Ascorbic acid, 99+%    50-81-7 500g 474.0CNY Detail
Alfa Aesar (A15613)  L-(+)-Ascorbic acid, 99+%    50-81-7 2500g 2006.0CNY Detail
Alfa Aesar (36237)  L-(+)-Ascorbic acid, ACS, 99+%    50-81-7 25g 210.0CNY Detail
Alfa Aesar (36237)  L-(+)-Ascorbic acid, ACS, 99+%    50-81-7 100g 373.0CNY Detail
Alfa Aesar (36237)  L-(+)-Ascorbic acid, ACS, 99+%    50-81-7 500g 1425.0CNY Detail

50-81-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name L-ascorbic acid

1.2 Other means of identification

Product number -
Other names L-Threoascorbic acid,Antiscorbutic factor,Vitamin C

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Processing Aids and Additives
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:50-81-7 SDS

50-81-7Synthetic route

dikegulac
18467-77-1

dikegulac

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With hydrogenchloride In toluene at 70℃; for 6h;94%
With hydrogenchloride; glycerol monostearate In Trichloroethylene at 50℃; for 0.0833333h; Kinetics; other temperatures, other times;
6-bromo-6-deoxy-(S)-ascorbic acid
62983-44-2

6-bromo-6-deoxy-(S)-ascorbic acid

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With sodium carbonate In water for 25h; Ambient temperature;89%
With sodium carbonate In water-d2 for 21h; pH: 9;
methyl 2-keto-3,5:4,6-di-O-ethylidene galactonate
144447-58-5

methyl 2-keto-3,5:4,6-di-O-ethylidene galactonate

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With hydrogenchloride; ethanol In dichloromethane at 60℃;83%
Methyl 2-keto-3,5:4,6-di-O-ethylidene-L-galactonate

Methyl 2-keto-3,5:4,6-di-O-ethylidene-L-galactonate

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With hydrogenchloride In ethanol; dichloromethane at 60℃; for 10h;83%
ethyl-3,5:4,6-di-O-methylene-L-lyxo-2-hexulosenate
74600-79-6

ethyl-3,5:4,6-di-O-methylene-L-lyxo-2-hexulosenate

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 4h; Heating;81.09%
(S)-4-[3,4-Bis-(4-methoxy-benzyloxy)-furan-2-yl]-2,2-dimethyl-[1,3]dioxolane
377089-24-2

(S)-4-[3,4-Bis-(4-methoxy-benzyloxy)-furan-2-yl]-2,2-dimethyl-[1,3]dioxolane

A

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

B

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With oxygen In methanol; tetrachloromethane at 20℃; for 7h; Photolysis;A n/a
B 74%
D-xylo-2-hexulosonic acid
21675-47-8

D-xylo-2-hexulosonic acid

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
In water at 160℃; under 7500.75 Torr;68%
L-xylo-[2]hexulosonic acid amide

L-xylo-[2]hexulosonic acid amide

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With methanol; ammonia
L-xylosone
3445-23-6

L-xylosone

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With potassium cyanide; hydrogen cyanide; water anschl. mit wss. HCl;
With potassium cyanide; water anschl. mit wss. HCl;
With hydrogen cyanide; ammonia; water anschl. mit wss. HCl;
With potassium cyanide; water; calcium chloride anschl. mit wss. HCl;
With potassium cyanide; water anschl. mit wss. HCl;
2-keto-L-gulonic acid
526-98-7

2-keto-L-gulonic acid

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With hydrogenchloride; water; butan-1-ol
With water at 100℃;
With hydrogenchloride; water
L-lyxo-[2]hexulosonic acid
91548-32-2

L-lyxo-[2]hexulosonic acid

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With hydrogenchloride; ethanol
With diazomethane; methanol; diethyl ether anschl. mit Blei(II)-acetat;
(3R,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxo-hexanoic acid methyl ester
1071558-27-4

(3R,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxo-hexanoic acid methyl ester

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With ethanol; triethylamine
With methanol; water
With methanol; sodium hydrogencarbonate
oxalic acid
144-62-7

oxalic acid

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With potassium bromate; cerium (IV) sulfate In sulfuric acid Belousov-Zhabotinski oscillation reaction;
methyl 2,5-di-O-acetyl-α-L-lyxo-hex-2-ulopyranosonate
143916-28-3

methyl 2,5-di-O-acetyl-α-L-lyxo-hex-2-ulopyranosonate

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With hydrogenchloride; sodium methylate 1.) MeOH, 20 min, room temperature; Yield given. Multistep reaction;
5,6-anhydro-L-ascorbic acid
85366-67-2

5,6-anhydro-L-ascorbic acid

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With water; sodium hydrogencarbonate; sodium carbonate at 24℃; pH: 8; variation of time;
C46H34O32

C46H34O32

A

geraniin
60976-49-0

geraniin

B

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
for 3h; oxidative metabolizm; enzyme from fresh leaves and stems of Geranium thunbergii;
L-dehydroascorbic acid
490-83-5

L-dehydroascorbic acid

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With potassium bromate; cerium (IV) sulfate In sulfuric acid Belousov-Zhabotinski oscillation reaction;
With isoascorbic acid In phosphate buffer at 20℃; for 24h; pH=7.4; Product distribution; Reduction;
With ethylenediaminetetraacetic acid; water; tris-(2-carboxyethyl)-phosphine hydrochloride; meta-phosphoric acid for 4h; pH=1.5; Cooling with ice;
With phosphoric acid In water at 25℃; for 0.5h; Darkness;
L-dehydroascorbic acid
490-83-5

L-dehydroascorbic acid

A

Red Pigment

Red Pigment

B

Reduced Red Pigment

Reduced Red Pigment

C

Tris(2-deoxy-2-L-ascorbyl)amine

Tris(2-deoxy-2-L-ascorbyl)amine

D

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With Phenylalanine In ethanol for 0.333333h; Product distribution; Mechanism; Heating; other times, other amino acids; also in the presence of ascorbic acid;
5a-tocopheryl ascorbate

5a-tocopheryl ascorbate

A

α‑tocopherol quinone
758720-42-2

α‑tocopherol quinone

B

vitamin E
18920-63-3

vitamin E

C

C58H96O4

C58H96O4

D

ascorbic acid
50-81-7

ascorbic acid

E

L-dehydroascorbic acid
490-83-5

L-dehydroascorbic acid

Conditions
ConditionsYield
With water In methanol for 24h; Mechanism; var. pH and time;
3,5-O-benzylidene-6-O-t-butyldimethylsilyl-L-xylo-hex-2-ulosonic acid 1,4-lactone 2-hydrate
216872-53-6

3,5-O-benzylidene-6-O-t-butyldimethylsilyl-L-xylo-hex-2-ulosonic acid 1,4-lactone 2-hydrate

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With water; acetic acid at 70 - 75℃; for 4h; Yield given;
With acetic acid at 80℃; for 4h; Yield given;
hydrogenchloride
7647-01-0

hydrogenchloride

O4,O6-isopropylidene-L-xylo-[2]hexulosonic acid butyl ester

O4,O6-isopropylidene-L-xylo-[2]hexulosonic acid butyl ester

ascorbic acid
50-81-7

ascorbic acid

(R)-2-((S)-1,2-dihydroxy-ethyl)-4-hydroxy-5-methoxy-furan-3-one
87804-24-8

(R)-2-((S)-1,2-dihydroxy-ethyl)-4-hydroxy-5-methoxy-furan-3-one

water
7732-18-5

water

ascorbic acid
50-81-7

ascorbic acid

water
7732-18-5

water

L-gulono-1,4-lactone
1128-23-0

L-gulono-1,4-lactone

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
Einwirkung von Roentgen-Strahlen;
Einwirkung von γ-Strahlen;
Einwirkung von Kathoden-Strahlen;
GLUTATHIONE
70-18-8

GLUTATHIONE

water
7732-18-5

water

L-dehydroascorbic acid
490-83-5

L-dehydroascorbic acid

ascorbic acid
50-81-7

ascorbic acid

hydrogen sulfide
7783-06-4

hydrogen sulfide

water
7732-18-5

water

L-dehydroascorbic acid
490-83-5

L-dehydroascorbic acid

ascorbic acid
50-81-7

ascorbic acid

water
7732-18-5

water

thioacetamide
62-55-5

thioacetamide

L-dehydroascorbic acid
490-83-5

L-dehydroascorbic acid

ascorbic acid
50-81-7

ascorbic acid

dikegulac
18467-77-1

dikegulac

aqueous hydrochloric acid (11n)

aqueous hydrochloric acid (11n)

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
at 60℃; Rate constant;
at 70℃; Rate constant;
dikegulac
18467-77-1

dikegulac

aqueous hydrochloric acid (5n)

aqueous hydrochloric acid (5n)

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
at 60℃; Rate constant;
at 70℃; Rate constant;
O2,O3;O4,O6-diisopropylidene-ξ-L-xylo-<2>hexofuranosonic acid methyl ester

O2,O3;O4,O6-diisopropylidene-ξ-L-xylo-<2>hexofuranosonic acid methyl ester

ascorbic acid
50-81-7

ascorbic acid

Conditions
ConditionsYield
With hydrogenchloride; ethanol; water
ascorbic acid
50-81-7

ascorbic acid

L-dehydroascorbic acid
490-83-5

L-dehydroascorbic acid

Conditions
ConditionsYield
With N-bromosaccharin; acetic acid for 0.0333333h; Ambient temperature;100%
With hexacyanoferrate(III) In water at 25℃; Mechanism; Rate constant; influence of pH (-1 to 1), ionic strength;
With starch-KI; chloroamine-T Product distribution; conditions for analytical determination, other halogenide used;
acetone
67-64-1

acetone

ascorbic acid
50-81-7

ascorbic acid

5,6-O-isopropylidene-L-ascorbic acid
15042-01-0

5,6-O-isopropylidene-L-ascorbic acid

Conditions
ConditionsYield
With Amberlite IR-120 for 2h; Heating;100%
With acetyl chloride at 7 - 20℃; for 11h;100%
With acetyl chloride at 40℃; for 2h;95%
vinyl palmitate
693-38-9

vinyl palmitate

ascorbic acid
50-81-7

ascorbic acid

Ascorbyl palmitate
137-66-6

Ascorbyl palmitate

Conditions
ConditionsYield
With Lipozyme TL IM In tert-Amyl alcohol at 40℃; Enzymatic reaction;100%
With phenylboronic acid; dmap 1.) water, t-BuOH, 2.) t-BuOH, 4 days, 25 deg C; Yield given. Multistep reaction;
2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

ascorbic acid
50-81-7

ascorbic acid

5,6-O-isopropylidene-L-ascorbic acid
15042-01-0

5,6-O-isopropylidene-L-ascorbic acid

Conditions
ConditionsYield
With hydrogenchloride; acetone for 1h;100%
With toluene-4-sulfonic acid In acetone100%
With hydrogenchloride In acetone for 1h;96.7%
sodium glycinate
6000-44-8

sodium glycinate

iron(II) chloride

iron(II) chloride

ascorbic acid
50-81-7

ascorbic acid

ferrous bisglycinate ascorbic acid chelate

ferrous bisglycinate ascorbic acid chelate

Conditions
ConditionsYield
In water at 55 - 60℃; for 4h;100%
ascorbic acid
50-81-7

ascorbic acid

strontium(II) L-ascorbic acid complex

strontium(II) L-ascorbic acid complex

Conditions
ConditionsYield
With strontium(II) carbonate for 1 - 2h; Product distribution / selectivity;100%
With strontium(II) carbonate In water at 80℃; for 7h;78%
With strontium hydroxide; strontium chloride In water at 30 - 50℃; Product distribution / selectivity;32%
4-(2-benzenesulfonylethyl)phenylamine
148960-51-4

4-(2-benzenesulfonylethyl)phenylamine

2-[2-(1,3-dioxan-2-yl)ethyl]-1-methylpyrrolidine fumarate
868618-74-0

2-[2-(1,3-dioxan-2-yl)ethyl]-1-methylpyrrolidine fumarate

ascorbic acid
50-81-7

ascorbic acid

3-(N-methyl-2(R)-pyrrolidinylmethyl)-5-(2-phenylsulphonylethyl)-1H-indole

3-(N-methyl-2(R)-pyrrolidinylmethyl)-5-(2-phenylsulphonylethyl)-1H-indole

Conditions
ConditionsYield
Stage #1: 4-(2-benzenesulfonylethyl)phenylamine With sulfuric acid; sodium nitrite In water; acetonitrile at 4℃; for 1h;
Stage #2: ascorbic acid In water; acetonitrile at 4 - 20℃; for 17h;
Stage #3: 2-[2-(1,3-dioxan-2-yl)ethyl]-1-methylpyrrolidine fumarate With potassium hydroxide Product distribution / selectivity; more than 3 stages;
100%
nicotinamide
98-92-0

nicotinamide

ascorbic acid
50-81-7

ascorbic acid

ascorbic acid,nicotinamide
114374-92-4

ascorbic acid,nicotinamide

Conditions
ConditionsYield
In water pH=Ca. 3.3 - 3.9; Cooling with ice;100%
In methanol33%
5'-(4-methylphenyl)-3'-[2-(methylthio)ethyl]-3a',6a'-dihydro-2'H-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrol]-2,4',6'(1H,3'H,5'H)-trione

5'-(4-methylphenyl)-3'-[2-(methylthio)ethyl]-3a',6a'-dihydro-2'H-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrol]-2,4',6'(1H,3'H,5'H)-trione

ascorbic acid
50-81-7

ascorbic acid

5′-(4-methylphenyl)-3′-[2-(methylthio)ethyl]-3a′,6a′-dihydro-2′H-spiro[indole-3,1′-pyrrolo[3,4-c]pyrrol]-2,4′,6′(1H,3′H,5′H)-trione L-ascorbic acid

5′-(4-methylphenyl)-3′-[2-(methylthio)ethyl]-3a′,6a′-dihydro-2′H-spiro[indole-3,1′-pyrrolo[3,4-c]pyrrol]-2,4′,6′(1H,3′H,5′H)-trione L-ascorbic acid

Conditions
ConditionsYield
In ethanol; water Heating;100%
nicotinic acid
59-67-6

nicotinic acid

ascorbic acid
50-81-7

ascorbic acid

niacin, ascorbic acid

niacin, ascorbic acid

Conditions
ConditionsYield
In water for 0.166667h; pH=Ca. 2.8 - 3; Cooling with ice;100%
ethanolamine
141-43-5

ethanolamine

ascorbic acid
50-81-7

ascorbic acid

2-hydroxyethylammonium ascorbate

2-hydroxyethylammonium ascorbate

Conditions
ConditionsYield
In methanol at 25℃;100%
palmitic anhydride
623-65-4

palmitic anhydride

ascorbic acid
50-81-7

ascorbic acid

Ascorbyl palmitate
137-66-6

Ascorbyl palmitate

Conditions
ConditionsYield
With dmap at 80℃; for 8h; Temperature; Reagent/catalyst;99.45%
pentadecanoic acid anhydride
59252-34-5

pentadecanoic acid anhydride

ascorbic acid
50-81-7

ascorbic acid

vitamin C pentadecanoate

vitamin C pentadecanoate

Conditions
ConditionsYield
With dmap at 80℃; for 8h;99.31%
ascorbic acid
50-81-7

ascorbic acid

2-ethylhexanoic acid chloride
760-67-8

2-ethylhexanoic acid chloride

C22H36O8

C22H36O8

Conditions
ConditionsYield
With pyridine; tetrabutylammomium bromide In ethyl acetate at 50℃; for 0.5h; Reagent/catalyst;99.3%
capric anhydride
2082-76-0

capric anhydride

ascorbic acid
50-81-7

ascorbic acid

6-O-caproyl L-ascorbate

6-O-caproyl L-ascorbate

Conditions
ConditionsYield
With dmap at 80℃; for 8h;99.21%
lauric acid
143-07-7

lauric acid

ascorbic acid
50-81-7

ascorbic acid

6-O-dodecanoyl-L-ascorbic acid
16690-40-7

6-O-dodecanoyl-L-ascorbic acid

Conditions
ConditionsYield
With Amberlyst 15 ion exchange resin In ethanol; water at 60℃; for 3h; Temperature;99.2%
With sulfuric acid
With sulfuric acid at 40℃;
With lipase from Candida antarctica type B (Chirazyme(R) L-2 C2) In acetone at 50℃;
With Chirazyme(R) L-2 C2 In acetone at 55℃; for 24h;
myristic anhydride
626-29-9

myristic anhydride

ascorbic acid
50-81-7

ascorbic acid

6-O-tetradecanoyl ascorbic acid
33425-76-2

6-O-tetradecanoyl ascorbic acid

Conditions
ConditionsYield
With dmap at 80℃; for 8h;99.14%
isononanoyl chloride
36727-29-4

isononanoyl chloride

ascorbic acid
50-81-7

ascorbic acid

C24H40O8

C24H40O8

Conditions
ConditionsYield
With pyridine; tetrabutylammomium bromide In ethyl acetate at 50℃; for 0.5h;99.1%
tridecanoic acid anhydride
53517-88-7

tridecanoic acid anhydride

ascorbic acid
50-81-7

ascorbic acid

vitamin C tridecanoate

vitamin C tridecanoate

Conditions
ConditionsYield
With dmap at 80℃; for 8h;99.01%
4-nitrobenzenediazonium tetrafluoroborate
456-27-9

4-nitrobenzenediazonium tetrafluoroborate

ascorbic acid
50-81-7

ascorbic acid

3-O-p-nitrobenzenediazoascorbic acid
121654-33-9

3-O-p-nitrobenzenediazoascorbic acid

Conditions
ConditionsYield
In water; acetonitrile for 0.5h;99%
1,1,1,3,3,3-hexamethyl-disilazane
999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

ascorbic acid
50-81-7

ascorbic acid

2,3,5,6-tetrakis-O-(trimethylsilyl) ascorbate
55517-56-1

2,3,5,6-tetrakis-O-(trimethylsilyl) ascorbate

Conditions
ConditionsYield
Stage #1: 1,1,1,3,3,3-hexamethyl-disilazane; ascorbic acid; trifluorormethanesulfonic acid In tetrahydrofuran at 66 - 70℃; for 6h;
Stage #2: With calcium carbonate In tetrahydrofuran for 2h;
Stage #3: With 1,1,1,3,3,3-hexamethyl-disilazane at 70℃; Product distribution / selectivity;
99%
In 1,2-dimethoxyethane at 50℃; for 8h; Product distribution / selectivity;95%
With pyridine at 100℃; for 2h;82%
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