157948-82-8Relevant academic research and scientific papers
Zirconocene-mediated synthesis of 3,4-disubstituted piperidines and reduced isoquinolines
Kemp, Mark I.,Whitby, Richard J.,Coote, Steven J.
, p. 557 - 568 (2007/10/03)
Intramolecular cocyclisation of 4-azaocta-1,7-dienes, -1-en-7-ynes, -7- en-1-ynes and -1,7-diynes using 'zirconocene' equivalents affords 3-aza-8- zirconabicyclo[4.3.0]nonanes, -6-enes, -9-enes or -6,9-dienes. Protonolysis, iodinolysis, or carbonylation of these complexes affords 3,4-disubstitued piperidines. Exocyclic 1,3-dienes formed from the coupling/protonolysis of 4- azaocta-1,7-diynes react with activated dienophiles to yield reduced isoquinolines.
Zinca-ene-allene cyclizations: A way to substituted tetrahydrofurans or pyrrolidines
Lorthiois, Edwige,Marek, Ilane,Normant, Jean-Francois
, p. 333 - 342 (2007/10/03)
Polysubstituted enynes have been lithiated on the propargylic position, and transmetalation to the corresponding zinc reagents promotes an easy cyclization reaction leading to polysubstituted tetrahydrofurans and pyrrolidines of definite geometry via the zinca-ene-allene reaction.Keywords: carbocyclization; allenyl zinc; tetrahydrofuran; pyrrolidine; zinca-ene-allene
