157977-22-5

Upstream product

• 157977-26-9 1-Ethyl-5-methoxy-2-(4-methoxyphenyl)-indol-3-carbaldehyd 
• 91444-30-3 1-Ethyl-5-methoxy-2-(4-methoxyphenyl)-indol 
• 5883-83-0 5-methoxy-2-(4-methoxyphenyl)-1H-indole 

Downstream Products

• 157977-24-7 2-(1-Ethyl-5-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-1,3-dinitropropan 
• 158611-40-6 2-(1-Ethyl-5-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl)-nitroethen 
• 158611-44-0 <1-Ethyl-5-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl>-methylidenmalonsaeuredinitril 

Relevant academic research and scientific papers

1,3-Dinitropropanes: Intermediates to 1,3-diaminopropanes

Reduction of malodinitriles 4 and 10 to the corresponding diamines does not work. - Reduction of dinitro-2-(indol-3-yl)-propanes 13 and 16 and subsequent reaction with K2PtCl4 afford the corresponding dichloroplatinum(II) complexes 14 and 17. Complexes 17 show weak binding affinities to the estrogen receptor and no antitumor activity towards MCF-7 and MDA-MB-2231-cell lines. - Twofold addition of nitromethane to aldehyde 24 is possible.

3-Substituted 2-phenylindoles: Synthesis and biological properties

Knoevenagel-reaction of indol-3-carbaldehydes 5a,b and 7a,b with nitromethane leads to the nitroethenes 12 and 14, the analogous reaction with malodinitrile to the methylidenemalonic acid dinitriles 16.- Michael-addition of nitromethane at 12 and 14 affor