157982-63-3

Basic information

• Product Name: tert-butyl N-(benzyloxycarbonyl)-2-(3-hydroxy-propyl)-pipecolate
• Synonyms: tert-butyl N-(benzyloxycarbonyl)-2-(3-hydroxy-propyl)-pipecolate
• CAS NO: 157982-63-3
• Molecular Weight: 377.481
• Mol File: 157982-63-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl N-(benzyloxycarbonyl)-2-(3-hydroxy-propyl)-pipecolate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl N-(benzyloxycarbonyl)-2-(3-hydroxy-propyl)-pipecolate(157982-63-3)
• EPA Substance Registry System: tert-butyl N-(benzyloxycarbonyl)-2-(3-hydroxy-propyl)-pipecolate(157982-63-3)

Safety Data

• Hazardous Substances Data: 157982-63-3(Hazardous Substances Data)

Upstream product

• 129605-87-4 tert-Butyl N-(benzyloxycarbonyl)-2(RS)-allylpipecolate 

Downstream Products

• 157982-64-4 tert-butyl N-(benzyloxycarbonyl)-2-(carboxyethyl)-pipecolate 
• 157982-70-2 C₂₂H₃₆N₂O₃Si₂ 
• 157982-71-3 10-Iodo-2-oxo-1-oxa-6-aza-spiro[4.5]decane-6-carboxylic acid benzyl ester 
• 157982-72-4 10-Iodo-2-oxo-1,6-diaza-spiro[4.5]decane-6-carboxylic acid benzyl ester 
• 157982-74-6 6-benzyloxycarbonyl-1,6-diazaspiro[4.5]decane-2-one 
• 157982-73-5 6-benzyloxycarbonyl-1-oxa-6-azaspiro[4.5]decan-2-one 
• 157982-69-9 3-(1'-benzyloxycarbonyl-1',4',5',6'-tetrahydropyridin-2'-yl)-propanamide 
• 157982-68-8 6-(2-Carboxy-ethyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester 
• 13618-93-4 indolizidine 
• 157982-65-5 tert-butyl N-(benzyloxycarbonyl)-2-(methoxycarbonylethyl)-pipecolate 
• 157982-66-6 N-(benzyloxycarbonyl)-2-(methoxycarbonylethyl)-pipecolic acid 
• 157982-67-7 methyl 3-(1'-benzyloxycarbonyl-1',4',5',6'-tetrahydropyridine-2'-yl)-propanoate 
• 2740-00-3 indolizidin-3-one 

Relevant articles and documents

Decarbonylation of α-tertiary amino acids application to the synthesis of polyhydroxylated indolizidines from D,L-pipecolic acid

The decarbonylation of the bicyclic α-tertiary carboxamido acid 11 led to the enamide 12, easily transformed into the indolizidine alkaloid 8,8a- trans-8-hydroxy-indolizidine 14. Likewise, the same process applied to the α-substituted pipecolic acid derivative 5 led to the unsaturated ester 6 which was easily transformed either into δ-coniceine 9 or to 14. The thermal fragmentation of the acyl derivative 22 led to the enamide 24 which has been transformed into (±)-swainsonine 26.