157982-73-5

Basic information

• Product Name: benzyl 2-oxo-1-oxa-6-azaspiro[4.5]decane-6-carboxylate
• Synonyms: Benzyl-2-oxo-1-oxa-6-azaspiro[4.5]decan-6-carboxylat
• CAS NO: 157982-73-5
• Molecular Formula: C₁₆H₁₉NO₄
• Molecular Weight: 289.3264
• Mol File: 157982-73-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 487.1°C at 760 mmHg
• Flash Point: 248.4°C
• Density: 1.25g/cm³
• Vapor Pressure: 1.22E-09mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: benzyl 2-oxo-1-oxa-6-azaspiro[4.5]decane-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 2-oxo-1-oxa-6-azaspiro[4.5]decane-6-carboxylate(157982-73-5)
• EPA Substance Registry System: benzyl 2-oxo-1-oxa-6-azaspiro[4.5]decane-6-carboxylate(157982-73-5)

Safety Data

• Hazardous Substances Data: 157982-73-5(Hazardous Substances Data)

Upstream product

• 157982-65-5 tert-butyl N-(benzyloxycarbonyl)-2-(methoxycarbonylethyl)-pipecolate 
• 157982-64-4 tert-butyl N-(benzyloxycarbonyl)-2-(carboxyethyl)-pipecolate 
• 157982-63-3 tert-butyl N-(benzyloxycarbonyl)-2-(3-hydroxy-propyl)-pipecolate 
• 129605-87-4 tert-Butyl N-(benzyloxycarbonyl)-2(RS)-allylpipecolate 
• 157982-66-6 N-(benzyloxycarbonyl)-2-(methoxycarbonylethyl)-pipecolic acid 
• 157982-67-7 methyl 3-(1'-benzyloxycarbonyl-1',4',5',6'-tetrahydropyridine-2'-yl)-propanoate 
• 157982-68-8 6-(2-Carboxy-ethyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester 
• 215106-50-6 6-benzyloxycarbonyl-10-iodo-1-oxa-6-azaspiro[4.5]decan-2-one 
• 157982-71-3 10-Iodo-2-oxo-1-oxa-6-aza-spiro[4.5]decane-6-carboxylic acid benzyl ester 

Relevant articles and documents

Synthesis of azaspiro[4.5]decane systems by oxidative cyclization of olefinic precursors

The synthesis of 6-benzyloxycarbonyl-1-oxa-6-azaspiro[4.5]decan-2-one (17) and 6-benzyloxycarbonyl-1,6-diazaspiro[4.5]decan-2-one (18) from the D,L-pipecolic acid derivative 10, is described. The synthesis of (±)-6- benzyl-3-methyl-1,6-diazaspiro[4.5]dec-3-ene-2,7-dione (29), the spiro structural unit of (±)-pandamarine (8) has been achieved by oxidative cyclization of the (Z) and (E) isomers of 5-(N-benzyl-4- carboxamidobutylidene)-3-methyl-3-pyrrolin-2-one (25) and (26). The stereoselectivity obtained in the intramolecular cyclization process has also been discussed.