1579992-45-2

Upstream product

• 1579992-53-2 (1S)-1-(4-((trimethylsilyl)ethynyl)phenyl)ethane-1,2-diol 
• 1579992-43-0 ethyl (S)-4-iodomandelate 
• 13704-09-1 (S)-(-)-ethyl mandelate 
• 17199-29-0 (S)-Mandelic acid 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 1579992-37-2 (1S)-1-(4-ethynylphenyl)ethane-1,2-diol 

Downstream Products

• 1579992-46-3 (S)-1-O-[(2-cyanoethyloxy)(N,N-diisopropylamino)phosphanyl]-2-(4,4'-dimethoxytrityloxy)-1-(4-ethynylphenyl)ethanol 

Relevant academic research and scientific papers

Synthesis of ethynylbenzene-substituted glycol as a versatile probe for labeling oligonucleotides

Positron emission tomography (PET) is a highly sensitive quantitative imaging technique for studying molecular pathways and interactions in vivo. This imaging technique plays a key role in drug discovery, pharmacokinetics, pharmacodynamics, and assessing in vivo distribution. In this study, we designed an ethynylbenzene-substituted glycol (ME) as a versatile probe for PET labeling of oligonucleotides through a click reaction.