1579992-53-2

Upstream product

• 31827-94-8 2-bromo-1-(4-iodophenyl)ethanone 
• 90842-69-6 (2-(4-iodophenyl)-2-oxoethyl) acetate 
• 1579992-43-0 ethyl (S)-4-iodomandelate 
• 13704-09-1 (S)-(-)-ethyl mandelate 
• 17199-29-0 (S)-Mandelic acid 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 1579992-37-2 (1S)-1-(4-ethynylphenyl)ethane-1,2-diol 
• 1579992-45-2 (S)-2-(4,4'-dimethoxytrityloxy)-1-(4-ethynylphenyl)ethanol 
• 1579992-46-3 (S)-1-O-[(2-cyanoethyloxy)(N,N-diisopropylamino)phosphanyl]-2-(4,4'-dimethoxytrityloxy)-1-(4-ethynylphenyl)ethanol 

Relevant academic research and scientific papers

NOVEL CRYSTALS OF HYDROXAMIC ACID DERIVATIVE, PRODUCTION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION

Crystals of (2S)-2-((4-((4-((1S)-1,2-dihydroxyethyl)phenyl)ethynyl)benzoyl)(methyl)amino)-N-hydroxy-N′,2-dimethylmalonamide having diffraction peaks at diffraction angles (2θ) of 3.8±0.2°, 7.7±0.2°, and 10.8±0.2°, etc., or 8.2±0.2°, 12.4±0.2°, and 13.3±0.2°, etc., in powder X-ray diffraction, a production method thereof, and a pharmaceutical composition.

NOVEL METHOD FOR PRODUCING HYDROXAMIC ACID DERIVATIVE, AND INTERMEDIATE THEREFOR

A novel method for production of hydroxamic acid derivative using a compound represented by the formula [12] as an intermediate, and intermediate therefor. wherein R1 represents a methyl group or the like; R2 represents a methyl group or the like; and R5 represents a hydrogen atom or the like.

Synthesis of ethynylbenzene-substituted glycol as a versatile probe for labeling oligonucleotides

Positron emission tomography (PET) is a highly sensitive quantitative imaging technique for studying molecular pathways and interactions in vivo. This imaging technique plays a key role in drug discovery, pharmacokinetics, pharmacodynamics, and assessing in vivo distribution. In this study, we designed an ethynylbenzene-substituted glycol (ME) as a versatile probe for PET labeling of oligonucleotides through a click reaction.