1580001-94-0

Basic information

• Product Name: 2,6-dichloro-4-(2,4,6-trimethylphenoxy)pyridine
• Synonyms: 2,6-dichloro-4-(2,4,6-trimethylphenoxy)pyridine
• CAS NO: 1580001-94-0
• Molecular Weight: 282.169
• Mol File: 1580001-94-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,6-dichloro-4-(2,4,6-trimethylphenoxy)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dichloro-4-(2,4,6-trimethylphenoxy)pyridine(1580001-94-0)
• EPA Substance Registry System: 2,6-dichloro-4-(2,4,6-trimethylphenoxy)pyridine(1580001-94-0)

Safety Data

• Hazardous Substances Data: 1580001-94-0(Hazardous Substances Data)

Upstream product

• 2402-78-0 2,6-dichloropyridine 
• 2587-00-0 2,6-dichloropyridine N-oxide 

Downstream Products

• 1580002-02-3 2-chloro-4-(mesityloxy)-6-methoxypyridine 
• 1580002-07-8 4-(mesityloxy)-6-methoxy-N-(4-nitrophenyl)pyridin-2-amine 
• 1580002-09-0 4-(mesityloxy)-6-methoxy-N-(p-tolyl)pyridin-2-amine 
• 1580002-10-3 4-((4-(mesityloxy)-6-methoxypyridin-2-yl)amino)benzonitrile 
• 1580052-84-1 4-(mesityloxy)-6-((4-nitrophenyl)amino)pyridin-2(1H)-one 
• 1580052-85-2 4-(mesityloxy)-6-(p-tolylamino)pyridin-2(1H)-one 
• 1580052-86-3 4-((4-(mesityloxy)-6-oxo-1,6-dihydropyridin-2-yl)amino)benzonitrile 
• 1580001-68-8 4-((5-iodo-4-(mesityloxy)-6-oxo-1,6-dihydropyridin-2-yl)amino)benzonitrile 
• 1580001-73-5 4-((5-bromo-4-(mesityloxy)-6-oxo-1,6-dihydropyridin-2-yl)amino)benzonitrile 
• 1580001-79-1 4-((5-chloro-4-(mesityloxy)-6-oxo-1,6-dihydropyridin-2-yl)amino)benzonitrile 

Relevant articles and documents

Structural optimization of pyridine-type DAPY derivatives to exploit the tolerant regions of the NNRTI binding pocket

Based on the crystallographic studies of diarylpyrimidines (DAPYs), we embarked on incorporating the hydrophilic piperidyl or morpholinyl group into the known DAPY derivatives bearing the pyridine moiety as a core structure, with the double aim to exploit additional interactions with the HIV-1 NNRTI binding pocket (NNIBP), as well as to improve the compound solubility. The antiviral evaluation result show that the most potent compounds I-8b2, I-8b3, I-8b4 and I-8c3 exhibited anti-HIV-1 (IIIB) strain activity ranging from 7.4 nM to 9.4 nM (SI = 168-1283), superior to FDA-approved drugs of nevirapine (NVP), lamivudine (3TC) and delavirdine (DLV), and comparable to etravirine (ETV), zidovudine (AZT) and efavirenz (EFV). Additionally, compounds I-8c2 and I-8c3 showed moderate activity against NNRTI resistant strains baring mutations K103N and Y181C with EC50 values of 6.2 mM and 6.8 mM, respectively. Preliminary structure-activity relationships (SARs), reverse transcriptase inhibition efficacy and molecular modeling of selected compounds are also presented. These outcomes support our design hypothesis and demonstrate that the piperidyl group modified pyridine-typed DAPY derivatives are highly potent NNRTIs with improved water solubility.

6-substitute diaryl pyridine derivative and preparing method and application thereof

The invention discloses a 6-substitute diaryl pyridine derivative and a preparing method and application thereof. The compound has a structure shown in a formula I. The invention further relates to a drug composition containing the compound with the structure in the formula I and provides application of the compound to preparation of anti-HIV drugs.