158022-24-3

Upstream product

• 2462-32-0 L-phenylalanine benzyl ester hydrochloride 
• 70669-15-7 benzyl (tert-butoxycarbonyl)-L-valyl-L-phenylalaninate 
• 13734-41-3 t-Boc-L-valine 
• 959162-66-4 Boc-valinyl-phenylalaninyl-methionine methyl ester 
• 108334-64-1 N-tert-butyloxycarbonyl-L-valyl-L-phenylalanine 

Downstream Products

• 1026681-56-0 (S)-2-{(S)-2-[(S)-2-(5-Chloro-2-hydroxy-benzoylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester 
• 1027891-65-1 (S)-2-{(S)-2-[(S)-2-(3-Chloro-4-hydroxy-benzoylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester 
• 1027591-17-8 (S)-2-{(S)-2-[(S)-2-(2-Hydroxy-4-methyl-benzoylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester 
• 1026328-79-9 (S)-2-{(S)-2-[(S)-2-(4-Hydroxy-3-methoxy-benzoylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester 
• 1026932-23-9 (S)-2-{(S)-2-[(S)-2-(3-Hydroxy-4-methoxy-benzoylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester 
• 1027605-22-6 (S)-2-{(S)-2-[(S)-2-(5-Bromo-2-hydroxy-benzoylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester 
• 1026487-54-6 (S)-2-{(S)-2-[(S)-2-(4-Chloro-2-hydroxy-benzoylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester 
• 1026037-79-5 (S)-2-{(S)-2-[(S)-2-(2-Hydroxy-4-methoxy-benzoylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester 
• 1027941-98-5 (S)-2-{(S)-2-[(S)-2-(3-Hydroxy-benzoylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester 
• 1027580-00-2 (S)-2-{(S)-2-[(S)-2-(2-Hydroxy-benzoylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester 
• 1026851-40-0 (S)-2-{(S)-2-[(S)-2-(4-Hydroxy-benzoylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester 
• 1166991-69-0 C₃₆H₅₃N₅O₈S 
• 1166991-70-3 C₃₆H₅₃N₅O₈S 
• 1166991-71-4 C₃₆H₅₃N₅O₈S 

Relevant academic research and scientific papers

Synthesis and biological evaluation of potential bisubstrate inhibitors of protein farnesyltransferase. Design and synthesis of functionalized imidazoles

A novel series of compounds, derived from 2,5-functionalized imidazoles, have been synthesized as potential bisubstrate inhibitors of protein farnesyltransferase (FTase) using structure-based design. These compounds have a 1,4-diacid chain and a tripeptid

Phenol-derived CVFM analog inhibitors of Ras farnesyltransferase possessing cellular in vitro activity

A study was performed on structure-activity relationships of a series of phenol-derived, CVFM analogs, inhibitors of Ras Farnesyltransferase (FTase). The effect of various substituents on the phenol ring was examined, while the VFM moiety of the potent inhibitor CVFM was kept constant. The FTase inhibitory activity, reported as IC50 in table I, was influenced by both the chemical properties and the relative position of the substituents on the phenolic ring. The most active compounds in this series contained a chloro or bromine substituent on the phenolic ring. Subsequently we have tested the effects of these FTase inhibitors on the anchorage-dependent growth of two rat epithelial cell lines, FRTL-5 and the same line v-Ha-ras transformed. While most of the compounds were inactive, two showed a growth inhibitory effect: compound 4 was active against normal as well against transformed cells while derivative 13 was active only against transformed cells.