15803-02-8

Basic information

• Product Name: 4-Bromo-1-methylpyrazole
• Synonyms: 4-BROMO-1-METHYL-1H-PYRAZOLE;4-Bromo-1-methylpyrazole;1-Mehtyl-4-Bromo-1H-Pyrazole;1-Methyl-4-bromo-1H-pyrazole;cyclopent-1-enecarbaldehyde;4-bromo-1-methyl-1H-pyrazole(SALTDATA: 0.2HBr);4-broMo-1-Methyl-1H-pyraz...;4-BroMo-1-Methyl-1H-pyrazole, 98+%
• CAS NO: 15803-02-8
• Molecular Formula: C₄H₅BrN₂
• Molecular Weight: 161
• EINECS: 1312995-182-4
• Product Categories: Azoles;blocks;Bromides;Halides;Pyrazoles & Triazoles;Organohalides;Pyrazole;CHIRAL CHEMICALS;Pyrazoles & Triazoles;Boronic Acid;Heterocyclic Compounds
• Mol File: 15803-02-8.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 185-188°C
• Flash Point: 93°C
• Appearance: Colorless to pale yellow/Liquid
• Density: 1.558
• Vapor Pressure: 0.543mmHg at 25°C
• Refractive Index: n20/D 1.531
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.21±0.10(Predicted)
• CAS DataBase Reference: 4-Bromo-1-methylpyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-1-methylpyrazole(15803-02-8)
• EPA Substance Registry System: 4-Bromo-1-methylpyrazole(15803-02-8)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39
• RIDADR: UN1760
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 15803-02-8(Hazardous Substances Data)

Usage

General Description

4-Bromo-1-methylpyrazole is a chemical compound with the molecular formula C5H6BrN2. It is a pyrazole derivative with a bromine atom and a methyl group attached to the pyrazole ring. 4-Bromo-1-methylpyrazole is commonly used in pharmaceutical and chemical research as a building block for the synthesis of various bioactive compounds. It is also known for its ability to inhibit certain enzymes and receptors, making it a potential candidate for drug development. Additionally, 4-Bromo-1-methylpyrazole is used in the preparation of organic compounds and can also be used as a reagent in organic synthesis. Due to its versatile properties, this chemical compound is of interest to researchers in various fields of chemistry and pharmacology.

InChI:InChI=1/C4H5BrN2/c1-7-3-4(5)2-6-7/h2-3H,1H3

Upstream product

• 930-36-9 1-methyl-1H-pyrazole 
• 2075-45-8 4-bromo-1H-pyrazole 
• 74-88-4 methyl iodide 
• 5952-92-1 1-methyl-1H-pyrazole-4-carboxylic acid 
• 74-83-9 methyl bromide 

Downstream Products

• 93331-04-5 (2-methyl-2H-pyrazol-3-yl)-diphenyl-methanol 
• 93331-03-4 (1-methyl-1H-pyrazol-4-yl)-diphenyl-methanol 
• 930-36-9 1-methyl-1H-pyrazole 
• 5952-92-1 1-methyl-1H-pyrazole-4-carboxylic acid 
• 84547-84-2 4-bromo-2-methyl-2H-pyrazole-3-carboxylic acid 
• 489468-66-8 4-[1-(4-fluorophenyl)-5-(1-methylpyrazol-4-yl)-1H-indol-3-yl]piperidine-1-carboxylic acid tert-butyl ester 
• 847818-55-7 (1-methyl-1H-pyrazol-4-yl)boronic acid 
• 16291-40-0 1-phenyltriphenylene 
• 1421928-72-4 (4-chloro-2-methylphenyl)(1-methyl-1H-pyrazol-4-yl)methanamine 
• 1415474-31-5 5-[6-chloro-2-methyl-1-(1-methyl-1H-pyrazol-4-yl)-1H-indol-3-ylsulfanyl]-nicotinic acid methyl ester 
• 1393879-88-3 4-(4-butylphenyl)-1-methyl-1H-pyrazole 
• 1401732-50-0 1-(4-methoxybenzyl)-3-methyl-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridine 
• 1401732-53-3 1-(4-methoxybenzyl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridine 
• 10199-69-6 1-methyl-4-phenyl-1H-pyrazole 

Relevant articles and documents

PIPERIDINYL-METHYL-PURINEAMINES AS NSD2 INHIBITORS AND ANTI-CANCER AGENTS

The present invention provides a compound of Formula (I): (I) or an enantiomer, an enantiomeric mixture, or a pharmaceutically acceptable salt thereof; wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating a disease or condition mediated by nuclear SET domain-containing protein 2 (NSD2).

Transition-metal-free decarboxylative bromination of aromatic carboxylic acids

Methods for the conversion of aliphatic acids to alkyl halides have progressed significantly over the past century, however, the analogous decarboxylative bromination of aromatic acids has remained a longstanding challenge. The development of efficient methods for the synthesis of aryl bromides is of great importance as they are versatile reagents in synthesis and are present in many functional molecules. Herein we report a transition metal-free decarboxylative bromination of aromatic acids. The reaction is applicable to many electron-rich aromatic and heteroaromatic acids which have previously proved poor substrates for Hunsdiecker-type reactions. In addition, our preliminary mechanistic study suggests that radical intermediates are not involved in this reaction, which is in contrast to classical Hunsdiecker-type reactivity. Overall, the process demonstrates a useful method for producing valuable reagents from inexpensive and abundant starting materials.

AUTOTAXIN INHIBITOR COMPOUNDS

Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorde