847818-55-7

Basic information

• Product Name: 1-Methyl-1H-pyrazole-4-boronic acid
• Synonyms: 1-Methyl-1H-pyrazole-4-boronic acid HCl;1-Methyl-1H-pyrazole-4-boronic acid hydrochloride ;1-Methyl-1h-pyrazol-4-yl-4-boronic acid;(1-Methyl-4-pyrazolyl)boronic acid;1-Methyl-1H-pyrazole-4-boronic acid;1-methyl-1H-pyrazol-4-ylboronic acid;REF DUPL: 1-Methyl-1H-pyrazole-4-boronic acid;1-Methyl-1H-pyrazole-4-boronic acid ,97%
• CAS NO: 847818-55-7
• Molecular Formula: C₄H₇BN₂O₂
• Molecular Weight: 125.92
• Product Categories: Pyrazole series;Boronic Acids & Esters;Pyrazoles & Triazoles;Boronic Acids & Esters;Pyrazoles & Triazoles
• Mol File: 847818-55-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 323 ºC
• Flash Point: 149 ºC
• Appearance: /
• Density: 1.23
• Vapor Pressure: 0.000111mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 7.77±0.10(Predicted)
• CAS DataBase Reference: 1-Methyl-1H-pyrazole-4-boronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1H-pyrazole-4-boronic acid(847818-55-7)
• EPA Substance Registry System: 1-Methyl-1H-pyrazole-4-boronic acid(847818-55-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37
• Hazardous Substances Data: 847818-55-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

Uses

Different sources of media describe the Uses of 847818-55-7 differently. You can refer to the following data:
1. 1-Methyl-1H-pyrazole-4-boronic acid is used in the synthesis of c-Met kinase inhibitor.
2. 1-Methyl-4-pyrazoleboronic Acid is used in the synthesis of c-Met kinase inhibitor.

InChI:InChI=1/C4H7BN2O2/c1-7-3-4(2-6-7)5(8)9/h2-3,8-9H,1H3

Upstream product

• 15803-02-8 4-bromo-1-methyl-1H-pyrazole 
• 73183-34-3 bis(pinacol)diborane 
• 1044733-61-0 C₁₀H₁₉BN₂O₂ 
• 930-36-9 1-methyl-1H-pyrazole 

Downstream Products

• 1270943-12-8 3-(4-chlorophenyl)-1,1'-dimethyl-5-propyl-1H,1'H-4,4'-bipyrazole 
• 1183623-74-6 2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzaldehyde 
• 943541-20-6 3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine 
• 1430200-07-9 C₂₉H₂₄FN₅O₃ 
• 1151801-90-9 2,3-difluoro-5-(1-methyl-1H-pyrazol-4-yl)pyridine 

Relevant articles and documents

Azaindazole bipyridine derivative myeloid cell proliferation inhibitor as well as preparation method and application thereof in pharmacy

The invention provides an azaindazole bipyridine derivative myeloid cell proliferation inhibitor shown as a formula I, wherein R1, R2 and R3 have the meanings defined in the specification of the invention. A compound in formula I can significantly inhibit proliferation and related disordersof myeloid cells represented by MOLM-16, HL-60, and MV-4-11. The formula I or salt thereof or the related pharmaceutical composition provided by the invention has excellent in-vivo and in-vitro inhibitory activity, good druggability, high bioavailability and no obvious damage to organs. Therefore, the compound shown in the formula I or the salt thereof and the related drug combination have huge clinical application prospects.

Preparation method of pyrazol compound

The invention belongs to the technical field of organic synthesis, particularly relates to a preparation method of a pyrazol compound, in more particular to a preparation method of 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxapentaborane-2-yl)-1H-pyrazol. The preparation method of the 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxapentaborane-2-yl)-1H-pyrazol comprises the following steps of by taking tetrahydrofuran and 1-methyl-4-bromo-pyrazol as raw materials, and performing reaction with triisopropyl borate and pinacol to prepare the 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxapentaborane-2-yl)-1H-pyrazol. The preparation method is liable in operation of the whole reaction process, available in raw material, low in cost and high in purity and yield of products.

Process development and large-scale synthesis of a c-Met kinase inhibitor

A highly convergent synthesis of c-Met kinase inhibitor 1 has been demonstrated on a multikilogram scale using three key fragments: dihalotricyclic core 2, chiral sulfamide side chain 3, and pyrazole boronic ester 4. The chirality in sulfamide side chain 3 was installed using the cheap and readily available starting material (S)-epichlorohydrin. A total of 2.71 kg of 1 were isolated in seven steps (the longest linear sequence).