15804-72-5Relevant articles and documents
Electrochemical Debromination of 1-Aryl-1,2-dibromo-2-nitropropanes in Dimethyl Sulfoxide
Cho, Bong Rae,Cho, Eun Jeong,Lee, Seung Jae,Chae, Won Seok
, p. 2077 - 2081 (1995)
Electrochemical debromination reactions of erythro-dl-1-aryl-1,2-dibromo-2-nitropropanes 1a-d at a platinum electrode have been investigated by cyclic voltammetry in 0.10 M LiClO4/DMSO.The reactions produced (E)-1-aryl-2-nitropropenes 2a-d in high yields.The cyclic voltammograms were irreversible and the reduction current decrease as the number of cycles increased.The peak potential for the reductions waves are in the range of -0.51 to -0.56 V (vs Ag/Ag(1+)) and show no clear trend with different aryl substituent.The current density increased as the concentration of the substrate increased.The slopes of the plots of log(I/A) vs log are close to unity, indicating unimolecular processes.For all reactions, the Tafel slopes are in the range of 115-125 mV.The logarithm of the ratio iX/iH at -0.16 V did not correlate with the Hammett substituent constants.From these results, the mechanism of these reactions is assessed.
Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
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Paragraph 0962; 0963, (2015/08/04)
The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds.
Highly enantioselective reduction of α-methylated nitroalkenes
Burda, Edyta,Re?, Tina,Winkler, Till,Giese, Carolin,Kostrov, Xenia,Huber, Tobias,Hummel, Werner,Gr?ger, Harald
supporting information, p. 9323 - 9326 (2013/09/12)
Highly selective: The reduction of α-methyl-substituted nitroalkenes succeeds in a highly enantioselective fashion with an ene reductase from Gluconobacter oxydans. Under optimized reaction conditions the desired nitroalkanes are formed with enantiomeric excesses of up to 95% in these biotransformations. Copyright