21906-32-1

Basic information

• Product Name: 3-BROMOPHENYLACETONE
• Synonyms: 3-BROMOPHENYLACETONE;1-(3-BROMOPHENYL)-2-PROPANONE;1-(3-BROMOPHENYL)PROPAN-2-ONE;TIMTEC-BB SBB005833;2-Propanone, 1-(3-bromophenyl)-;3-Bromophenylacetone,99%;1-(3-broMophenyl)-;3-BroMophenylacetone, 99% 5GR
• CAS NO: 21906-32-1
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213.07
• Product Categories: Aromatic Ketones (substituted)
• Mol File: 21906-32-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 247.5°C (rough estimate)
• Flash Point: 75.9 °C
• Appearance: Clear light yellow to dark yellow/Liquid
• Density: 1.3841 (rough estimate)
• Vapor Pressure: 0.00903mmHg at 25°C
• Refractive Index: 1.557-1.56
• CAS DataBase Reference: 3-BROMOPHENYLACETONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMOPHENYLACETONE(21906-32-1)
• EPA Substance Registry System: 3-BROMOPHENYLACETONE(21906-32-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-52
• Safety Statements: 24/25
• Hazardous Substances Data: 21906-32-1(Hazardous Substances Data)

Usage

Chemical Properties

clear light yellow liquid

InChI:InChI=1/C9H9BrO/c1-7(11)5-8-3-2-4-9(10)6-8/h2-4,6H,5H2,1H3

Upstream product

• 15804-72-5 1-bromo-3-[2-nitroprop-1-enyl]benzene 
• 108-86-1 bromobenzene 
• 67-64-1 acetone 
• 108-22-5 Isopropenyl acetate 
• 591-19-5 m-Bromoaniline 
• 78191-00-1 N-Methoxy-N-methylacetamide 
• 30118-02-6 2-(3-bromo-phenyl)-acetoacetonitrile 
• 98288-51-8 2-(3-bromophenyl)acetyl chloride 
• 506-82-1 dimethylcadmium 
• 108-36-1 1,3-dibromobenzene 
• 1878-67-7 3-Bromophenylacetic acid 
• 917-54-4 methyllithium 
• 31938-07-5 (3-bromophenyl)acetonitrile 

Downstream Products

• 66952-36-1 1-bromo-3-(prop-1-yn-1-yl)benzene 
• 1184574-05-7 1-(3-bromophenyl)propan-2-ol 
• 53993-67-2 N-ethyl-1-(3-((trifluoromethyl)thio)phenyl)propan-2-amine 
• 605681-02-5 3-(3-bromophenyl)-4-(5-chloro-2-pyridyl)-2-butanol 
• 808769-12-2 3-(2-tert-butoxycarbonylamino-2-methylpropyl)benzoic acid methyl ester 
• 808769-13-3 [2-(3-bromophenyl)-1,1-dimethylethyl]carbamic acid tert-butyl ester 
• 808769-15-5 N-[2-(3-bromophenyl)-1,1-dimethylethyl]-2-chloroacetamide 
• 808769-11-1 methyl 3-(2-amino-2-methylpropyl)benzoate 
• 808769-14-4 1-(3-bromophenyl)-2-methylpropan-2-amine 
• 917897-74-6 C₈H₁₁N*C₁₁H₁₀BrNO₃ 
• 917897-73-5 C₁₁H₁₀BrNO₃ 
• 917897-72-4 C₁₁H₁₀BrNO₃ 

Relevant articles and documents

Asymmetric Catalytic Epoxidation of Terminal Enones for the Synthesis of Triazole Antifungal Agents

An enantioselective epoxidation of α-substituted vinyl ketones was realized to construct the key epoxide intermediates for the synthesis of various triazole antifungal agents. The reaction proceeded efficiently in high yields with good enantioselectivities by employing a chiral N,N′-dioxide/ScIII complex as the chiral catalyst and 35% aq. H2O2 as the oxidant. It enabled the facile transformation for optically active isavuconazole, efinaconazole, and other potential antifungal agents.

β-fluoroamphetamines via the stereoselective synthesis of benzylic fluorides

A range of substituted aryl epoxides undergo efficient ring-opening hydrofluorination upon treatment with 0.33 equiv of BF3-OEt 2 in CH2Cl2 at -20 -°C to give the corresponding syn-fluorohydrins, consistent with a mechanism involving a stereoselective SN1-type epoxide ring-opening process. The benzylic fluoride products of these reactions are valuable templates for further elaboration, as demonstrated by the preparation of a range of aryl-substituted β-fluoroamphetamines.

SUBSTITUTED SULFONAMIDES

The substituted sulfonamides of the invention are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.