1580436-07-2

Upstream product

• 210967-30-9 C₂₀H₁₇NO₂ 
• 53560-33-1 3,4,5-trimethoxyphenylacetylene 
• 17702-41-9 nido-decaborane 
• 1580436-06-1 C₂₀H₁₅IO₂ 
• 185698-55-9 2-(3-hydroxy-4-methoxyphenyl)-1-(3',4',5'-trimethoxyphenyl)ethyne 

Relevant academic research and scientific papers

Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors

Diaryl-substituted ortho-carboranes 1 were synthesized from the corresponding alkynes by decaborane coupling under microwave-irradiated conditions with a combination of N,N-dimethylaniline and chlorobenzene. Among the compounds synthesized, 1a and 1d exhibited significant inhibition of hypoxia-induced HIF-1 transcriptional activity. Both compounds similarly suppressed hypoxia-induced HIF-1α accumulation in a concentration- dependent manner without affecting HIF-1α mRNA expression.