1580470-83-2

Upstream product

• 120-72-9 indole 
• 526-55-6 2-(3-indole)-ethanol 
• 18372-22-0 2-(3-indolyl)oxoacetic acid methyl ester 
• 501-53-1 benzyl chloroformate 
• 101079-48-5 3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1H-indole 

Downstream Products

• 391612-42-3 (3aR,8aS)-benzyl 3a-hydroxy-3,3a-dihydro-2H-furo[2,3-b]indole-8(8aH)-carboxylate 
• 1580471-46-0 (3aR,8aS)-benzyl 3,3a-dihydro-2H-furo[2,3-b]indole-8(8aH)-carboxylate 
• 1580471-47-1 (3aR,8aS)-benzyl 3a-(p-tolyl)-3,3a-dihydro-2H-furo[2,3-b]indole-8(8aH)-carboxylate 
• 849360-65-2 (3aR,8aS)-benzyl 3a-allyl-3,3a-dihydro-2H-furo[2,3-b]indole-8(8aH)-carboxylate 
• 1580470-72-9 benzyl 3-(2-hydroxyethyl)-1H-indole-1-carboxylate 
• 1580471-24-4 (3aR,8aS)-benzyl 3a-bromo-3,3a-dihydro-2H-furo[2,3-b]indole-8(8aH)-carboxylate 

Relevant academic research and scientific papers

An environmentally friendly protocol for oxidative halocyclization of tryptamine and tryptophol derivatives

An environmentally friendly and efficient protocol (KX/oxone) for oxidative halocyclization of tryptamine/tryptophol derivatives was developed and demonstrated with 28 examples and concise total synthesis of cyclotryptamine alkaloid protubonines A and B. The distinct advantage of this protocol over all previous methods is that no organic byproduct is generated from a halogenating agent or oxidant, thus greatly reducing the environmental impact of halocyclization and facilitating the post-reaction purification.

Highly asymmetric bromocyclization of tryptophol: Unexpected accelerating effect of DABCO-derived bromine complex

Highly asymmetric bromocyclization of tryptophol by using chiral anionic phase-transfer catalyst and DABCO-derived brominating reagent is described. Optimization of the reaction conditions revealed that the reaction rate was accelerated together with impr