1580483-62-0Relevant articles and documents
2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors
Costales, Abran,Mathur, Michelle,Ramurthy, Savithri,Lan, Jiong,Subramanian, Sharadha,Jain, Rama,Atallah, Gordana,Setti, Lina,Lindvall, Mika,Appleton, Brent A.,Ornelas, Elizabeth,Feucht, Paul,Warne, Bob,Doyle, Laura,Basham, Stephen E.,Aronchik, Ida,Jefferson, Anne B.,Shafer, Cynthia M.
, p. 1592 - 1596 (2014/03/21)
2-Amino-7-substituted benzoxazole analogs were identified by HTS as inhibitors of RSK2. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus of improving in vitro and target modulation potency and physicochemical properties.