1580491-03-7

Basic information

• Product Name: C₁₃H₁₉BrN₂OS
• CAS NO: 1580491-03-7
• Molecular Weight: 331.277
• Mol File: 1580491-03-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₉BrN₂OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₉BrN₂OS(1580491-03-7)
• EPA Substance Registry System: C₁₃H₁₉BrN₂OS(1580491-03-7)

Safety Data

• Hazardous Substances Data: 1580491-03-7(Hazardous Substances Data)

Upstream product

• 1580490-98-7 C₁₀H₁₀BrNS 
• 156-87-6 propan-1-ol-3-amine 
• 102236-50-0 2-bromo-3,4,6-trimethylaniline 

Relevant articles and documents

Structure-activity relationship of dihydroimidazo-, dihydropyrimido, tetrahydrodiazepino-[2,1-b]-thiazoles, and -benzothiazoles as an acylation catalyst

Cyclic isothioureas 1, 2, 3, and 4 were synthesized through a four-step procedure from the corresponding ortho-bromoanilines 10 via Pd- or Cu-catalyzed cyclization-benzothiazole formation. Nonbenzo analogues 7, 8, and 9 were synthesized by a condensation reaction of cyclic thioureas 15 and α-bromoacetophenones 14. Investigations of the acylation reactions of 1-phenylethanol with acid anhydrides in the presence of these cyclic isothiourea catalysts revealed their structure-activity relationships. Remarkable electronic effects resulting from substituent(s) on a benzo or phenyl moiety and the influence of the size of the annulating ring were observed. Introduction of an electron-donating substituent(s) enhanced the reaction rate. A few substitution effects on chiral catalysts of type 3 and 7 were also studied.