158089-79-3Relevant academic research and scientific papers
Antirheumatic
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, (2008/06/13)
A novel antirheumatic agent comprising as an active ingredient a compound of formula I: or a pharmaceutically acceptable salt or hydrate thereof.
Novel antiarthritic agents with 1,2-isothiazolidine-1-,1-dioxide (γ- sultam) skeleton: Cytokine suppressive dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase
Inagaki, Masanao,Tsuri, Tatsuo,Jyoyama, Hirokuni,Ono, Takashi,Yamada, Katsutoshi,Kobayashi, Mika,Hori, Yozo,Arimura, Akinori,Yasui, Kiyoshi,Ohno, Kouji,Kakudo, Shinji,Koizumi, Kenzo,Suzuki, Ryuji,Kato, Miyako,Kawai, Shinichi,Matsumoto, Saichi
, p. 2040 - 2048 (2007/10/03)
Various 1,2-isothiazolidine-1,1-dioxide (γ-sultam) derivatives containing an antioxidant moiety, 2,6-di-tert-butylphenol substituent, were prepared. Some compounds, which have a lower alkyl group at the 2-position of the γ-sultam skeleton, showed potent i
Benzylidene derivatives
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, (2008/06/13)
Benzylidene derivatives having anti-inflammatory activities, are shown by the following formula I: STR1 wherein A is -CH2 - or -CH2 CH2 -; B is a bond or -CH2 -, -CHOH-, -CO-, -O-, or A and B may taken together
Synthetic studies on condensed-azole derivatives. II. Application of a computer-assisted automated synthesis apparatus for the synthesis of N- substituted sulfamoylpropylthioimidazo[1,2-b]pyridazines
Kuwahara,Kato,Sugawara,Miyake
, p. 1511 - 1515 (2007/10/03)
For the purpose of improving the anti-asthmatic activity of 3- (imidazo[1,2-b]pyridazin-6-yl)thiopropanesulfonamide (I), the computer- assisted automated synthesis apparatus developed at Takeda was used to modify the sulfonamide moiety of I. Several kinds
